Compensatory mechanisms in higher-educated subjects with Alzheimer’s disease: a study of 20 years of cognitive decline

• Published in: Brain (London, England : 1878) Vol. 137; no. 4; pp. 1167 - 1175
• Main Authors: Amieva, Hélène, Mokri, Hind, Le Goff, Mélanie, Meillon, Céline, Jacqmin-Gadda, Hélène, Foubert-Samier, Alexandra, Orgogozo, Jean-Marc, Stern, Yaakov, Dartigues, Jean-François
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.2014
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alzheimer Disease - psychology; Biological and medical sciences; Case-Control Studies; Cognitive Reserve; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Progression; Educational Status; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Neuropsychological Tests; Organic mental disorders. Neuropsychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Human; Nervous system diseases; Cognitive disorder; cognitive decline trajectories; education; Alzheimer disease; Central nervous system disease; Degenerative disease; compensatory mechanisms; Trajectory; Alzheimer's disease; Cerebral disorder; Alzheimer’s disease

A better knowledge of long-term trajectories of cognitive decline is a central feature of the study of the process leading to Alzheimer's dementia. Several factors may mitigate such decline, among which is education, a major risk factor for Alzheimer's disease. The aim of our work was to c...