A probabilistic approach to compact steady-state kinetic equations for enzymic reactions

• Published in: Journal of theoretical biology Vol. 242; no. 3; pp. 627 - 633
• Main Authors: Malygin, Ernst G., Hattman, Stanley
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 07.10.2006
• Subjects: Animals; Computer Simulation; Enzymes - metabolism; Kinetics; Models, Chemical; Probability; Reaction graph; Scheme simplification; Scheme simplification; Probability; Reaction graph

We describe a method for deriving kinetic equations based on the simplification of a complex graphical scheme of steady-state enzymic reactions to one that is comprised of an unbranched pathway. It entails compressing unbranched multi-step sequences into one step, and fusing some graph nodes into a...