Effects of Extracellular Matrix Changes Induced by a High-Fat Diet on Gallbladder Smooth Muscle Dysfunction

• Published in: Frontiers in bioscience (Landmark. Print) Vol. 29; no. 12; p. 401
• Main Authors: Zhong, Xingguo, Wu, Feiyang, Gao, Weicheng, Hu, Jinlong, Shen, Bing, Zhong, Kaiyuan, Peng, Junbin, Zhang, Chong, Zhang, Chao
• Format: Journal Article
• Language: English
• Published: Singapore IMR Press 27.11.2024
• Subjects: Animals; Cells, Cultured; Collagen - metabolism; Diet, High-Fat - adverse effects; extracellular matrix; Extracellular Matrix - metabolism; Gallbladder - metabolism; Gallbladder - pathology; Gallbladder - physiopathology; gallbladder smooth muscle; gallstone; Guinea Pigs; high-fat diet; integrins family; Male; Matrix Metalloproteinases - metabolism; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth - metabolism; Muscle, Smooth - pathology; Muscle, Smooth - physiopathology; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Phosphatidylinositol 3-Kinases - metabolism; pi3k-akt signaling pathway; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; gallstone; PI3K-Akt signaling pathway; gallbladder smooth muscle; integrins family; extracellular matrix; high-fat diet

Background: Gallstone formation is a common digestive ailment, with unclear mechanisms underlying its development. Dysfunction of the gallbladder smooth muscle (GSM) may play a crucial role, particularly with a high-fat diet (HFD). This study aimed to investigate the effects of an HFD on GSM and ass...