Palladium-catalysed electrophilic aromatic C–H fluorination

• Published in: Nature (London) Vol. 554; no. 7693; pp. 511 - 514
• Main Authors: Yamamoto, Kumiko, Li, Jiakun, Garber, Jeffrey A. O., Rolfes, Julian D., Boursalian, Gregory B., Borghs, Jannik C., Genicot, Christophe, Jacq, Jérôme, van Gastel, Maurice, Neese, Frank, Ritter, Tobias
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.02.2018; Nature Publishing Group
• Subjects: 119/118; 140/131; 639/638/403/933; 639/638/77/888; Agrochemicals; Aromatic compounds; Brain; Catalysis; Chemical bonds; Drug development; Fluorides; Fluorination; Fluorine; Functional groups; Humanities and Social Sciences; Hydrogen; letter; Ligands; Methods; multidisciplinary; Palladium; Pharmaceutical industry; Pharmaceuticals; Reagents; Science; Substrates

An approach for the direct electrophilic C–H fluorination of arenes is reported, using a palladium catalyst and mild fluorinating reagents. Palladium-propelled C–H fluorination In the pharmaceutical industry, fluorine has long been added to organic molecules to improve the bioavailability of drugs....