Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma

• Published in: Oncotarget Vol. 7; no. 28; pp. 43239 - 43255
• Main Authors: Lee, Sung Hee, Rigas, Nicole Kristina, Lee, Chang-Ryul, Bang, April, Srikanth, Sonal, Gwack, Yousang, Kang, Mo K, Kim, Reuben H, Park, No-Hee, Shin, Ki-Hyuk
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 12.07.2016
• Subjects: Animals; Carcinogenesis - metabolism; Carcinoma, Squamous Cell - pathology; Cell Line, Tumor; Cell Movement; Disease Progression; Humans; Immunohistochemistry; Isoenzymes - metabolism; Keratinocytes; Mice; Mice, Nude; Microscopy, Confocal; Mouth Neoplasms - pathology; Mutation; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; NFATC Transcription Factors - genetics; NFATC Transcription Factors - metabolism; ORAI1 Protein - genetics; ORAI1 Protein - metabolism; Oropharyngeal Neoplasms - pathology; Research Paper; Retinal Dehydrogenase - metabolism; RNA Interference; RNA, Small Interfering - metabolism; Signal Transduction; Spheroids, Cellular; Xenograft Model Antitumor Assays; Orai1; SOCE; OSCC; cancer stem cells; NFAT

Emerging evidence indicates that Orai1, a key calcium channel for store-operated Ca2+ entry, is associated with human cancer. However, the underlying mechanism by which Orai1 regulates cancer progression remains unknown. Here we report that intracellular level of Orai1 is increased in a stepwise man...