Clinical significance of miR-21 expression in breast cancer : SYBR-Green I-based real-time RT-PCR study of invasive ductal carcinoma

• Published in: Oncology reports Vol. 21; no. 3; pp. 673 - 679
• Main Authors: HUANG, Guan-Li, ZHANG, Xiao-Hua, GUO, Gui-Long, HUANG, Ka-Te, YANG, Kai-Yan, XIAN SHEN, JIE YOU, HU, Xiao-Qu
• Format: Journal Article
• Language: English
• Published: Athens Spandidos 01.03.2009
• Subjects: Biological and medical sciences; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - metabolism; Carcinoma, Ductal, Breast - pathology; Female; Gynecology. Andrology. Obstetrics; Humans; Immunohistochemistry; Mammary gland diseases; Medical sciences; MicroRNAs - biosynthesis; Neoplasm Staging; Organic Chemicals; PTEN Phosphohydrolase - biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; Tumors; microRNAs; Breast disease; RNA interference; RNA-directed DNA polymerase; Breast tumor; breast neoplasms; tumor suppressor; Cancerology; Genetics; SYBR-Green I; PTEN Gene; Invasive cancer; Reverse transcription polymerase chain reaction; Tumor suppressor gene; Human; Ductal carcinoma; Enzyme; genes; Transferases; Micro RNA; oncogenes; Breast cancer; Malignant tumor; Real time; microRNA-21; Mammary gland diseases; Gene silencing; reverse transcriptase-polymerase chain reaction; Nucleotidyltransferases; PTEN phosphohydrolase; Molecular biology; Onc gene; Green; Cancer

Growing evidence suggests microRNAs (miRNAs) have an important role in tumorigenesis. MicroRNA-21 (miR-21) is up-regulated in many malignant tumors, including breast cancer. Its association with clinicopathologic features and expression of PTEN (phosphatase and tensin homolog deleted on chromosome 1...