The viable bioengineered allogeneic cellularized construct StrataGraft® synthesizes, deposits, and organizes human extracellular matrix proteins into tissue type-specific structures and secretes soluble factors associated with wound healing

• Published in: Burns Vol. 50; no. 2; pp. 424 - 432
• Main Authors: Steiglitz, Barry M., Maher, Robert J., Gratz, Kenneth R., Schlosser, Sandra, Foster, Jenna, Pradhan-Bhatt, Swati, Comer, Allen R., Allen-Hoffmann, B. Lynn
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2024
• Subjects: Extracellular matrix proteins; Organotypic culture; Skin regeneration; Soluble peptide factors; Wound healing; PBS; DE; Wound healing; HGF; Extracellular matrix proteins; Organotypic culture; DEJ; DPT; DAPI; Skin regeneration; CICP; VEGF-A; ECM; bFGF; MMP; GM-CSF; NHDF; SDF-1α; Soluble peptide factors; TGF-β1; PlGF; ELISA

StrataGraft® (allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen–dsat) is an FDA-approved viable bioengineered allogeneic cellularized construct for adult patients with deep partial-thickness burns requiring surgery. We characterized the structural and functional properties...