Excessive lithium of water induced a toxic effect on kidney via oxidative damage and inflammation in carp

• Published in: Aquaculture Vol. 535; p. 736282
• Main Authors: Jing, Hongyuan, Zhang, Qirui, Gao, Xue-jiao
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 30.03.2021
• Subjects: antioxidants; aquaculture; body fluids; Carp; dose response; hematologic tests; histology; Inflammation; interleukin-10; kidneys; Lithium; MAPKs pathway; Oxidative stress; phosphorylation; toxicity; Oxidative stress; GSH-Px; Carp; IL; Lithium; SOD; TSC2; Inflammation; JNKs; GSK-3β; ERKs; TOR; CAT; ROS; MAPKs pathway; TGF-β; Li; MAPKs

Lithium (Li) is ingested by the animal body and will be distributed throughout the body fluid environment. The model of carp with lithium exposing was established to study the effects of Li on oxidative damage and inflammatory response to kidneys. The histological analysis showed that the kidney inh...