A novel class of anti-IL-12p40 antibodies Potent neutralization via inhibition of IL-12-IL-12Rβ2 and IL-23-IL-23R
While current therapeutic antibodies bind to IL-12 and IL-23 and inhibit their binding to IL-12Rβ1, we describe a novel antibody, termed 6F6, that binds to IL-12 and IL-23 and inhibits the interaction of IL-12 and IL-23 with their cognate signalling receptors IL-12Rβ2 and IL23R. This antibody does n...
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Published in | mAbs Vol. 2; no. 5; pp. 539 - 549 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Taylor & Francis
01.09.2010
Landes Bioscience |
Subjects | |
Online Access | Get full text |
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