Biodistribution and brain permeability of the extracellular domain of neuregulin-1-β1

• Published in: Neuropharmacology Vol. 61; no. 8; pp. 1413 - 1418
• Main Authors: Rösler, Thomas W., Depboylu, Candan, Arias-Carrión, Oscar, Wozny, Wojciech, Carlsson, Thomas, Höllerhage, Matthias, Oertel, Wolfgang H., Schrattenholz, André, Höglinger, Günter U.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2011
• Subjects: Analysis of Variance; Animals; Autoradiography; Blood kinetics; Blood–brain barrier; Brain - drug effects; Brain - metabolism; Brain permeability; Distribution; Humans; Iodine Radioisotopes - pharmacokinetics; Male; Mice; Mice, Inbred C57BL; Neuregulin-1; Neuregulin-1 - genetics; Neuregulin-1 - metabolism; Neuregulin-1 - pharmacokinetics; Permeability - drug effects; Phosphorylation; Protein Structure, Tertiary - genetics; Protein Structure, Tertiary - physiology; Receptor, Epidermal Growth Factor - metabolism; Receptor, ErbB-4; Time Factors; Tissue Distribution - physiology; Neuregulin-1; Blood kinetics; Brain permeability; Distribution; Blood–brain barrier

Neuregulin-1 (NRG1) belongs to a large family of growth and differentiation factors with a key role in the development and maintenance of the brain. Genetic association of NRG1 within brain disorders such as Alzheimer’s disease, schizophrenia and neuroprotective properties of certain NRG1 isoforms h...