The association analysis of lncRNA HOTAIR genetic variants and gastric cancer risk in a Chinese population

• Published in: Oncotarget Vol. 6; no. 31; pp. 31255 - 31262
• Main Authors: Du, Mulong, Wang, Weizhi, Jin, Hua, Wang, Qiaoyan, Ge, Yuqiu, Lu, Jiafei, Ma, Gaoxiang, Chu, Haiyan, Tong, Na, Zhu, Haixia, Wang, Meilin, Qiang, Fulin, Zhang, Zhengdong
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 13.10.2015
• Subjects: Biomarkers, Tumor - genetics; Case-Control Studies; China - epidemiology; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Homeodomain Proteins - genetics; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Polymerase Chain Reaction; Polymorphism, Single Nucleotide - genetics; Prognosis; Promoter Regions, Genetic - genetics; Research Paper; Risk Factors; RNA, Long Noncoding - genetics; Stomach Neoplasms - epidemiology; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; China; HOTAIR; genetic variants; long noncoding RNA; gastric cancer

The HOX transcript antisense intergenic RNA (HOTAIR), a well-known long noncoding RNA, is involved in pathogenesis and progress of multiple tumors. Its ectopic expression and biological functions have been observed in gastric cancer. In this study, we conducted a two-stage case-control study to eval...