Regulation of hepcidin: Insights from biochemical analyses on human serum samples

• Published in: Blood cells, molecules, & diseases Vol. 40; no. 3; pp. 339 - 346
• Main Authors: Kemna, Erwin H.J.M., Kartikasari, April E.R., van Tits, Lambertus J.H., Pickkers, Peter, Tjalsma, Harold, Swinkels, Dorine W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2008
• Subjects: Algorithms; Anemia, Iron-Deficiency - blood; Anemia, Iron-Deficiency - metabolism; Antimicrobial Cationic Peptides - blood; beta-Thalassemia - blood; beta-Thalassemia - metabolism; C-Reactive Protein - analysis; Cell Line; Erythropoiesis; Female; Ferritins - blood; Hepcidin; Hepcidins; Humans; Inflammation - blood; Inflammation - metabolism; Iron; Iron - blood; Iron deficiency; Iron Metabolism Disorders - blood; Iron Metabolism Disorders - metabolism; Male; Metabolic Networks and Pathways; Protein Precursors - blood; Receptors, Transferrin - blood; sTfR; Thalassemia; Transferrin - analysis; sTfR; Thalassemia; Iron; Iron deficiency; Hepcidin

Knowledge of hepcidin regulation is foremost gained by in vitro studies. We aimed to translate this knowledge into the human in vivo situation. Therefore, we measured serum markers as transferrin saturation (TS), soluble transferrin receptor (sTfR), and C-reactive protein (CRP) in parallel with hepc...