Adult Cancer Clinical Trials That Fail to Complete: An Epidemic?

• Published in: JNCI : Journal of the National Cancer Institute Vol. 106; no. 9; p. 1
• Main Authors: Stensland, Kristian D., McBride, Russell B., Latif, Asma, Wisnivesky, Juan, Hendricks, Ryan, Roper, Nitin, Boffetta, Paolo, Hall, Simon J., Oh, William K., Galsky, Matthew D.
• Format: Journal Article
• Language: English
• Published: United States Oxford Publishing Limited (England) 01.09.2014
• Subjects: Adult; Antineoplastic Agents - economics; Cancer; Clinical trials; Clinical Trials as Topic - statistics & numerical data; Clinical Trials as Topic - trends; Drug Discovery - economics; Early Termination of Clinical Trials - statistics & numerical data; Early Termination of Clinical Trials - trends; Humans; National Cancer Institute (U.S.); Neoplasms - drug therapy; Prescription drugs; R&D; Research & development; Research Subjects; United States - epidemiology; United States

The number and diversity of cancer therapeutics in the pipeline has increased over the past decade due to an enhanced understanding of cancer biology and the identification of novel therapeutic targets. At the same time, the cost of bringing new drugs to market and the regulatory burdens associated...