Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosa

• Published in: International journal of oncology Vol. 29; no. 1; pp. 83 - 94
• Main Authors: BIANCHINI, Michele, LEVY, Estrella, ZUCCHINI, Cinzia, PINSKI, Victor, MACAGNO, Carlos, DE SANCTIS, Paola, VALVASSORI, Luisa, CARINCI, Paolo, MORDOH, José
• Format: Journal Article
• Language: English
• Published: Athens Editorial Academy of the International Journal of Oncology 01.07.2006
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Adult; Aged; Aged, 80 and over; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; beta 2-Microglobulin - genetics; beta 2-Microglobulin - metabolism; Biological and medical sciences; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - metabolism; HLA Antigens - genetics; HLA Antigens - metabolism; HLA-E Antigens; Humans; Intestinal Mucosa - metabolism; Male; Medical sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Middle Aged; Neuronal Apoptosis-Inhibitory Protein - genetics; Neuronal Apoptosis-Inhibitory Protein - metabolism; Oligonucleotide Array Sequence Analysis - methods; Reproducibility of Results; RNA, Messenger - analysis; RNA, Messenger - metabolism; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Human; anti-apoptotic phenotype; Rectal disease; Mucosa; Colorectal cancer; cDNA microarray; Malignant tumor; Gene expression; Gene expression profile; Colonic disease; Phenotype; Colon cancer; Cancerology; Complementary DNA; Gene; Tissue microarrays; gene expression profiles; Digestive diseases; Intestinal disease; Comparative study; Apoptosis

The causative molecular pathways underlying the pathogenesis of colorectal cancer (CRC) need to be better characterized. The purpose of our study was to better understand the genetic mechanism of oncogenesis for human colorectal cancer and to identify new potential tumor markers of use in clinical p...