Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia

• Published in: Oncotarget Vol. 7; no. 16; pp. 21713 - 21727
• Main Authors: Takam Kamga, Paul, Bassi, Giulio, Cassaro, Adriana, Midolo, Martina, Di Trapani, Mariano, Gatti, Alessandro, Carusone, Roberta, Resci, Federica, Perbellini, Omar, Gottardi, Michele, Bonifacio, Massimiliano, Nwabo Kamdje, Armel Hervé, Ambrosetti, Achille, Krampera, Mauro
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 19.04.2016
• Subjects: Acute Disease; Adult; Aged; Bone Marrow Cells - metabolism; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Drug Resistance, Neoplasm - drug effects; Female; HL-60 Cells; Humans; K562 Cells; Leukemia, Myeloid - metabolism; Leukemia, Myeloid - pathology; Male; Mesenchymal Stromal Cells - metabolism; Middle Aged; Oligopeptides - pharmacology; Receptors, Notch - antagonists & inhibitors; Receptors, Notch - metabolism; Research Paper; Signal Transduction; Tumor Cells, Cultured; U937 Cells; AML; chemoresistance; MSC; Notch

Both preclinical and clinical investigations suggest that Notch signalling is critical for the development of many cancers and for their response to chemotherapy. We previously showed that Notch inhibition abrogates stromal-induced chemoresistance in lymphoid neoplasms. However, the role of Notch in...