Epigenetic Repression of Interleukin 2 Expression in Senescent CD4⁺ T Cells During Chronic HIV Type 1 Infection - Nakayama-Hosoya, Kaori; Ishida, Takaomi; Youngblood, Ben; Nakamura, Hitomi; Hosoya, Noriaki; Koga, Michiko; Koibuchi, Tomohiko; Iwamoto, Aikichi; Kawana-Tachikawa, Ai (The Journal of infectious diseases, 2015)
Keywords: Adult; CD4-Positive T-Lymphocytes - immunology; CD57 Antigens - immunology; Cells, Cultured; CpG Islands; DNA Methylation; Epigenetic Repression; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - metabolism; HIV-1 - immunology; HIV/AIDS; Humans; Immunologic Memory; Interleukin-2 - biosynthesis; Interleukin-2 - genetics; Interleukin-2 - immunology; Leukocytes, Mononuclear - immunology; Middle Aged; Promoter Regions, Genetic; HIV-1; DNA methylation; repression of IL-2 expression; immunosenescence; T-cell differentiation; CD4+ T-cell dysfunction