Signals from the niche promote distinct modes of translation initiation to control stem cell differentiation and renewal in the Drosophila testis

• Published in: PLoS biology Vol. 23; no. 3; p. e3003049
• Main Authors: Wang, Ruoxu, Roiuk, Mykola, Storer, Freya, Teleman, Aurelio A., Amoyel, Marc
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.03.2025; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Cell Differentiation; Drosophila melanogaster - cytology; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Eukaryotic Initiation Factor-4F - genetics; Eukaryotic Initiation Factor-4F - metabolism; Janus Kinases - metabolism; Male; Medicine and Health Sciences; Peptide Chain Initiation, Translational; Protein Biosynthesis; Research and Analysis Methods; Signal Transduction; STAT Transcription Factors - metabolism; Stem Cell Niche; Stem Cells - cytology; Stem Cells - metabolism; Testis - cytology; Testis - metabolism

Stem cells have the unique ability among adult cells to give rise to cells of different identities. To do so, they must change gene expression in response to environmental signals. Much work has focused on how transcription is regulated to achieve these changes; however, in many cell types, transcri...