Mapping of a macular drusen susceptibility locus in rhesus macaques to the homologue of human chromosome 6q14-15

• Published in: Experimental eye research Vol. 81; no. 4; pp. 401 - 406
• Main Authors: Singh, Krishna K., Ristau, Steven, Dawson, William W., Krawczak, Michael, Schmidtke, Jörg
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2005
• Subjects: ageing macular dystrophy; Animals; Chromosome Mapping - methods; Chromosomes, Human, Pair 6 - genetics; Disease Models, Animal; disease susceptibility; drusen; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Haplotypes; Humans; Macaca mulatta; Macular Degeneration - genetics; retina; Retinal Drusen - genetics; Macaca mulatta; disease susceptibility; retina; ageing macular dystrophy; drusen

Rhesus macaques (Macaca mulatta) are a natural model for retinal drusen formation. The present study aimed at clarifying whether chromosomal regions homologous to candidate genes for drusen formation and progression in humans are also associated with a drusen phenotype in rhesus macaques. Some 42 ge...