MicroRNA-7 as a tumor suppressor and novel therapeutic for adrenocortical carcinoma

• Published in: Oncotarget Vol. 6; no. 34; pp. 36675 - 36688
• Main Authors: Glover, Anthony R, Zhao, Jing Ting, Gill, Anthony J, Weiss, Jocelyn, Mugridge, Nancy, Kim, Edward, Feeney, Alex L, Ip, Julian C, Reid, Glen, Clarke, Stephen, Soon, Patsy S H, Robinson, Bruce G, Brahmbhatt, Himanshu, MacDiarmid, Jennifer A, Sidhu, Stan B
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 03.11.2015
• Subjects: Adrenal Cortex Neoplasms - genetics; Adrenal Cortex Neoplasms - therapy; Adrenocortical Carcinoma - genetics; Adrenocortical Carcinoma - therapy; Animals; Cell Line, Tumor; Cell Proliferation; Female; Genetic Therapy - methods; Humans; Immunohistochemistry; Mice; Mice, Nude; MicroRNAs - administration & dosage; MicroRNAs - genetics; Prognosis; Random Allocation; Research Paper; RNA, Untranslated - genetics; Transfection - methods; Xenograft Model Antitumor Assays; miR-7; noncoding RNA; adrenal cancer; nanoparticle therapy

Adrenocortical carcinoma (ACC) has a poor prognosis with significant unmet clinical need due to late diagnosis, high rates of recurrence/metastasis and poor response to conventional treatment. Replacing tumor suppressor microRNAs (miRNAs) offer a novel therapy, however systemic delivery remains chal...