Diffusion tensor magnetic resonance imaging for single subject diagnosis in neurodegenerative diseases

• Published in: Brain (London, England : 1878) Vol. 136; no. 7; pp. 2253 - 2261
• Main Authors: Sajjadi, Seyed A., Acosta-Cabronero, Julio, Patterson, Karalyn, Diaz-de-Grenu, Lara Z., Williams, Guy B., Nestor, Peter J.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2013
• Subjects: Aged; Alzheimer Disease - complications; Analysis of Variance; Anisotropy; Aphasia, Primary Progressive - etiology; Biological and medical sciences; Brain - metabolism; Brain - pathology; Brain Mapping; Case-Control Studies; Cognition Disorders - etiology; Cohort Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Diffusion Magnetic Resonance Imaging; Female; Frontotemporal Lobar Degeneration - complications; Humans; Male; Medical sciences; Middle Aged; Nerve Fibers, Myelinated - pathology; Neurodegenerative Diseases - complications; Neurodegenerative Diseases - pathology; Neurology; Neuropsychological Tests; Supranuclear Palsy, Progressive - complications; Human; Nervous system diseases; corticobasal degeneration; Supranuclear ophthalmoplegia; neurodegeneration; Nuclear magnetic resonance imaging; Cerebral disorder; Diffusion tensor imaging; Eye disease; Anatomic pathology; Central nervous system disease; tau pathology; Degenerative disease; Degeneration; Diagnosis; Oculomotor syndrome; Brain stem syndrome; progressive supranuclear palsy; diffusion tensor imaging, neurodegeneration

Although magnetic resonance imaging is a standard investigation in neurodegenerative disease, sensitive and specific markers for the underlying histopathological diagnosis are largely lacking. This report presents evidence to indicate that corticobasal degeneration and progressive supranuclear palsy...