Expression of the extracellular sulfatase SULF2 is associated with squamous cell carcinoma of the head and neck

• Published in: Oncotarget Vol. 7; no. 28; pp. 43177 - 43187
• Main Authors: Flowers, Sarah A, Zhou, Xin, Wu, Jing, Wang, Yiwen, Makambi, Kepher, Kallakury, Bhaskar V, Singer, Mark S, Rosen, Steven D, Davidson, Bruce, Goldman, Radoslav
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 12.07.2016
• Subjects: Adult; Aged; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Carcinogenesis - metabolism; Carcinoma, Squamous Cell - blood; Carcinoma, Squamous Cell - pathology; Enzyme-Linked Immunosorbent Assay; Female; Head and Neck Neoplasms - blood; Head and Neck Neoplasms - pathology; Heparan Sulfate Proteoglycans - metabolism; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Staging; Research Paper; Saliva - metabolism; Squamous Cell Carcinoma of Head and Neck; Sulfatases; Sulfotransferases - analysis; Sulfotransferases - metabolism; sulfation; tumorigenesis; cancer progression; biomarker; heparan sulfate proteoglycans

Sulfatase 2 (SULF2), an extracellular sulfatase that alters sulfation on heparan sulfate proteoglycans, is involved in the tumorigenesis and progression of several carcinomas. SULF2 expression has not been evaluated in squamous cell carcinoma of the head and neck (HNSCC). Here we report results of I...