Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C
We present the case of a 53-year-old woman who developed systemic lupus erythematosus (SLE) after being treated with interferon-alpha (IFN-alpha) for cryoglobulinemic vasculitis associated with hepatitis C virus (HCV) infection. Her cryoglobulinemic vasculitis resolved rapidly with IFN-alpha treatme...
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| Published in | Clinical rheumatology Vol. 24; no. 2; pp. 178 - 181 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Springer Nature B.V
01.04.2005
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| Abstract | We present the case of a 53-year-old woman who developed systemic lupus erythematosus (SLE) after being treated with interferon-alpha (IFN-alpha) for cryoglobulinemic vasculitis associated with hepatitis C virus (HCV) infection. Her cryoglobulinemic vasculitis resolved rapidly with IFN-alpha treatment. However, after 10 months of IFN-alpha therapy, she developed a photosensitive malar rash, oral ulcers, arthralgias, lymphopenia, and anti-SSA autoantibodies. She was diagnosed with SLE induced by IFN-alpha therapy. IFN-alpha was discontinued, she was treated with a short course of prednisone and hydroxychloroquine, and she improved rapidly. This is the first report of IFN-alpha-induced SLE complicating treatment of cryoglobulinemic vasculitis associated with HCV infection. The development of SLE during therapy with IFN-alpha could be due to direct immunomodulation by IFN-alpha, and review of experimental data and prior case reports suggests a pathogenic role for IFN-alpha in SLE. |
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| AbstractList | We present the case of a 53-year-old woman who developed systemic lupus erythematosus (SLE) after being treated with interferon-alpha (IFN-α) for cryoglobulinemic vasculitis associated with hepatitis C virus (HCV) infection. Her cryoglobulinemic vasculitis resolved rapidly with IFN-α treatment. However, after 10 months of IFN-α therapy, she developed a photosensitive malar rash, oral ulcers, arthralgias, lymphopenia, and anti-SSA autoantibodies. She was diagnosed with SLE induced by IFN-α therapy. IFN-α was discontinued, she was treated with a short course of prednisone and hydroxychloroquine, and she improved rapidly. This is the first report of IFN-α-induced SLE complicating treatment of cryoglobulinemic vasculitis associated with HCV infection. The development of SLE during therapy with IFN-α could be due to direct immunomodulation by IFN-α, and review of experimental data and prior case reports suggests a pathogenic role for IFN-α in SLE. We present the case of a 53-year-old woman who developed systemic lupus erythematosus (SLE) after being treated with interferon-alpha (IFN-alpha) for cryoglobulinemic vasculitis associated with hepatitis C virus (HCV) infection. Her cryoglobulinemic vasculitis resolved rapidly with IFN-alpha treatment. However, after 10 months of IFN-alpha therapy, she developed a photosensitive malar rash, oral ulcers, arthralgias, lymphopenia, and anti-SSA autoantibodies. She was diagnosed with SLE induced by IFN-alpha therapy. IFN-alpha was discontinued, she was treated with a short course of prednisone and hydroxychloroquine, and she improved rapidly. This is the first report of IFN-alpha-induced SLE complicating treatment of cryoglobulinemic vasculitis associated with HCV infection. The development of SLE during therapy with IFN-alpha could be due to direct immunomodulation by IFN-alpha, and review of experimental data and prior case reports suggests a pathogenic role for IFN-alpha in SLE. |
| Author | Swedler, William I Niewold, Timothy B |
| Author_xml | – sequence: 1 givenname: Timothy B surname: Niewold fullname: Niewold, Timothy B email: niewoldt@hss.edu organization: Department of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA. niewoldt@hss.edu – sequence: 2 givenname: William I surname: Swedler fullname: Swedler, William I |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15565395$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1097/00007611-199608000-00012 10.1016/0090-1229(92)90250-R 10.1016/S0002-9343(03)00390-5 10.1111/j.1365-2796.1990.tb00144.x 10.1093/rheumatology/33.8.787 10.1002/ajh.2830410215 10.1002/art.1780251101 10.1002/1097-0142(19911001)68:7<1536::AID-CNCR2820680713>3.0.CO;2-B 10.1126/science.1064890 10.1002/1529-0131(200007)43:7<1431::AID-ANR3>3.0.CO;2-E 10.1016/S0022-3476(05)80913-8 10.1002/1097-0142(19900515)65:10<2237::AID-CNCR2820651013>3.0.CO;2-5 |
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| Snippet | We present the case of a 53-year-old woman who developed systemic lupus erythematosus (SLE) after being treated with interferon-alpha (IFN-alpha) for... We present the case of a 53-year-old woman who developed systemic lupus erythematosus (SLE) after being treated with interferon-alpha (IFN-α) for... |
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| SubjectTerms | Autoantibodies Autoimmune diseases Blood diseases Case reports Cryoglobulinemia - drug therapy Cryoglobulinemia - virology Female Hepatitis Hepatitis C Hepatitis C, Chronic - complications Humans Hydroxychloroquine Immunologic Factors - adverse effects Immunologic Factors - immunology Immunomodulation Interferon-alpha - adverse effects Interferon-alpha - immunology Lupus Lupus Erythematosus, Systemic - chemically induced Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - immunology Lymphopenia Middle Aged Prednisone Systemic lupus erythematosus Ulcers Vasculitis Vasculitis - drug therapy Vasculitis - virology α-Interferon |
| Title | Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C |
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