Mechanism of Cd²⁺ on DNA cleavage and Ca²⁺ on DNA repair in liver of silver crucian carp

• Published in: Fish physiology and biochemistry Vol. 34; no. 1; pp. 43 - 51
• Main Authors: Wu, Cheng, Wang, Ling, Liu, Chao, Gao, Fengqing, Su, Mingyu, Wu, Xiao, Hong, Fashui
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : Springer Netherlands 01.03.2008; Springer Netherlands; Springer Nature B.V
• Subjects: agarose; Animal Anatomy; Animal Biochemistry; Animal Physiology; Animals; Antioxidants; apoptosis; Biomedical and Life Sciences; Cadmium; Cadmium - pharmacology; Cadmium and calcium; calcium; Calcium - pharmacology; Carassius gibelio; Carcinogenicity; catalase; deoxyribonucleases; Deoxyribonucleic acid; DNA; DNA Cleavage - drug effects; DNA damage; DNA repair; DNA Repair - drug effects; DNase activity; Enzymes - metabolism; Freshwater & Marine Ecology; gel electrophoresis; Goldfish - metabolism; Heavy metals; Histology; Life Sciences; lipid peroxidation; Lipid Peroxidation - drug effects; liver; Liver - drug effects; Liver - enzymology; Liver - metabolism; metal ions; Morphology; peroxidase; Peroxidation; reactive oxygen species; Reactive Oxygen Species - metabolism; ROS; Silver; Silver crucian carp; superoxide dismutase; Zoology; Cadmium and calcium; Silver crucian carp; DNase activity; DNA; ROS

The subject of acute injury, apoptosis and canceration of animals induced by heavy metal ions has been one of the hotspots studied worldwide. However, the exact molecular mechanism of Cd-induced carcinogenicity remains largely unclear, and how to relieve the toxicity in vivo has rarely been reported...