Circulating cardiovascular biomarkers during and after preeclampsia: Crosstalk with placental function?
Cardiovascular disease (CVD) is the leading cause of death in women, yet sex-specific risk factors remain understudied. Preeclampsia and other adverse pregnancy outcomes imply an increased maternal cardiovascular risk. We hypothesized that cardiac troponin T (cTnT), N-terminal pro-Brain Natriuretic...
Saved in:
Published in | Pregnancy hypertension Vol. 30; pp. 103 - 109 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English Norwegian |
Published |
01.12.2022
|
Online Access | Get full text |
Cover
Loading…
Abstract | Cardiovascular disease (CVD) is the leading cause of death in women, yet sex-specific risk factors remain understudied. Preeclampsia and other adverse pregnancy outcomes imply an increased maternal cardiovascular risk. We hypothesized that cardiac troponin T (cTnT), N-terminal pro-Brain Natriuretic Peptide (NT-proBNP) and growth differentiation factor 15 (GDF-15) are increased in such pregnancies and correlate with markers of placental dysfunction. We also investigated these cardiovascular biomarkers 1 or 3 years postpartum.
Prior to delivery, we included serum from 417 pregnant women: 55 early-onset preeclampsia (EO-PE), 63 late-onset preeclampsia (LO-PE), 30 gestational hypertension (GH) and 269 healthy controls. Postpartum, we included 341 women 1 or 3 years after delivery: 26 EO-PE, 107 LO-PE, 61 GH, and 147 healthy pregnancies.
Prior to delivery, median cTnT and NT-proBNP concentrations were higher in women with EO-PE, LO-PE, or GH than in controls. Median GDF-15 was higher in EO-PE and LO-PE compared to controls. Postpartum, GDF-15 was elevated in women with previous EO-PE. Markers of placental dysfunction correlated with CVD biomarkers in pregnancy, but not postpartum.
Our findings underscore the cardiovascular burden of hypertensive disorders of pregnancy and the crosstalk with placental function. The upregulation of circulating GDF-15 following early-onset preeclampsia is in line with the epidemiological excessive risk of premature CVD in this group of women. GDF-15 may be explored for targeting postpartum women with most to gain from intensified preventive follow-up for CVD. |
---|---|
AbstractList | Cardiovascular disease (CVD) is the leading cause of death in women, yet sex-specific risk factors remain understudied. Preeclampsia and other adverse pregnancy outcomes imply an increased maternal cardiovascular risk. We hypothesized that cardiac troponin T (cTnT), N-terminal pro-Brain Natriuretic Peptide (NT-proBNP) and growth differentiation factor 15 (GDF-15) are increased in such pregnancies and correlate with markers of placental dysfunction. We also investigated these cardiovascular biomarkers 1 or 3 years postpartum.
Prior to delivery, we included serum from 417 pregnant women: 55 early-onset preeclampsia (EO-PE), 63 late-onset preeclampsia (LO-PE), 30 gestational hypertension (GH) and 269 healthy controls. Postpartum, we included 341 women 1 or 3 years after delivery: 26 EO-PE, 107 LO-PE, 61 GH, and 147 healthy pregnancies.
Prior to delivery, median cTnT and NT-proBNP concentrations were higher in women with EO-PE, LO-PE, or GH than in controls. Median GDF-15 was higher in EO-PE and LO-PE compared to controls. Postpartum, GDF-15 was elevated in women with previous EO-PE. Markers of placental dysfunction correlated with CVD biomarkers in pregnancy, but not postpartum.
Our findings underscore the cardiovascular burden of hypertensive disorders of pregnancy and the crosstalk with placental function. The upregulation of circulating GDF-15 following early-onset preeclampsia is in line with the epidemiological excessive risk of premature CVD in this group of women. GDF-15 may be explored for targeting postpartum women with most to gain from intensified preventive follow-up for CVD. |
Author | Sugulle, Meryam Strand, Heidi Omland, Torbjørn Moe, Kjartan Røysland, Ragnhild Staff, Anne Cathrine Jacobsen, Daniel P. |
Author_xml | – sequence: 1 givenname: Daniel P. surname: Jacobsen fullname: Jacobsen, Daniel P. – sequence: 2 givenname: Ragnhild surname: Røysland fullname: Røysland, Ragnhild – sequence: 3 givenname: Heidi surname: Strand fullname: Strand, Heidi – sequence: 4 givenname: Kjartan surname: Moe fullname: Moe, Kjartan – sequence: 5 givenname: Meryam surname: Sugulle fullname: Sugulle, Meryam – sequence: 6 givenname: Torbjørn surname: Omland fullname: Omland, Torbjørn – sequence: 7 givenname: Anne Cathrine surname: Staff fullname: Staff, Anne Cathrine |
BookMark | eNo9kMtKAzEUhoMoWGvfQDBLNx1zm1zciBRvUHCj65DJZNq008yYzCh9e1OqBg5JDh__4XwX4DR0wQFwhVGBEea3m6KPbrXeFwQRUiBVIERPwIQQjOZCKHH6_5bqHMxS2qB8WImk4BOwWvhox9YMPqygNbH23ZdJh06Ele92Jm5dTLAe4wEwoYamGVyEeaazrdn1yZs7uIhdSoNpt_DbD2vYt8a6kP-wGYMdfBfuL8FZY9rkZr_3FHw8Pb4vXubLt-fXxcNybmnJhjlmja14pawlVklJBJOYiZoJXsmSEiqdaipCsZWSVXXtGspycVNzRTNK6RRcH3Nt9CkvpUMXjcZIlkQryYXKxM2R6GP3Obo06J1P1rWtCa4bkyYCC644KWVG2V9Y3i-6RvfRZyX7HKgP8vVGH-Xrg3yNlM7y6Q8dp3w6 |
CitedBy_id | crossref_primary_10_1016_j_ejogrb_2024_04_007 crossref_primary_10_1016_j_preghy_2024_101127 crossref_primary_10_1001_jamacardio_2023_4994 crossref_primary_10_1016_j_mce_2023_112075 |
Cites_doi | 10.1128/MCB.00444-09 10.1002/uog.22070 10.1161/CIR.0000000000000582 10.1053/j.semperi.2009.02.010 10.1016/j.jjcc.2011.07.009 10.1001/jama.2010.1768 10.1177/2047487319879791 10.1253/circj.CJ-18-0375 10.1161/HYPERTENSIONAHA.109.130583 10.1093/eurheartj/ehy339 10.1097/HJH.0000000000002497 10.1371/journal.pone.0162957 10.1080/10641955.2018.1524477 10.1161/CIR.0000000000000617 10.1097/HJH.0b013e3283300541 10.1159/000292452 10.1016/j.amjmed.2018.11.017 10.1080/00016340600569133 10.1161/HYPERTENSIONAHA.115.06357 10.1097/SHK.0000000000000811 10.1038/s41390-019-0633-z 10.1161/01.HYP.0000054981.03589.E9 10.1016/S0002-9149(02)02464-5 10.1056/NEJMoa0805299 10.1081/PRG-120021060 10.1016/j.amjcard.2007.11.025 10.1371/journal.pone.0133362 10.1161/CIRCULATIONAHA.116.023005 10.1016/j.cyto.2016.05.002 10.5603/KP.2013.0262 10.1373/clinchem.2014.234369 10.1007/s10741-014-9447-6 10.1161/JAHA.120.020302 10.1161/HYPERTENSIONAHA.107.098046 10.1002/uog.19040 10.1161/01.HYP.36.2.220 10.1016/S0378-1119(97)00485-X 10.1111/j.1474-9726.2010.00629.x 10.1210/endo.134.6.8194476 10.1016/j.preghy.2011.08.122 10.1161/HYPERTENSIONAHA.111.176537 10.1016/j.jri.2020.103249 |
ContentType | Journal Article |
Copyright | info:eu-repo/semantics/openAccess |
Copyright_xml | – notice: info:eu-repo/semantics/openAccess |
DBID | AAYXX CITATION 7X8 3HK |
DOI | 10.1016/j.preghy.2022.09.003 |
DatabaseName | CrossRef MEDLINE - Academic NORA - Norwegian Open Research Archives |
DatabaseTitle | CrossRef MEDLINE - Academic |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 2210-7797 |
EndPage | 109 |
ExternalDocumentID | 10852_98679 10_1016_j_preghy_2022_09_003 |
GroupedDBID | --- --K --M -RU .1- .FO .~1 0R~ 1P~ 1~. 4.4 457 4G. 53G 7-5 8P~ AACTN AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAWTL AAXKI AAXUO AAYXX ABBQC ABJNI ABMAC ABMZM ABXDB ACDAQ ACGFS ACRLP ADBBV ADEZE AEBSH AEKER AEVXI AFCTW AFJKZ AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV CITATION EBS EFJIC EJD FDB FEDTE FIRID FNPLU FYGXN GBLVA HVGLF HZ~ KOM M41 MO0 O-L O9- OAUVE OQ. P-8 P-9 PC. PH~ Q38 RIG ROL SDF SEL SES SSH SSZ T5K XH2 Z5R ~G- 7X8 3HK AAIAV AALMO ABLVK ABPIF ABYKQ AJBFU LCYCR |
ID | FETCH-LOGICAL-c354t-14fcb6b9cc2c9882748147d476b853238e9fb231c884bddef34ef36ad69348133 |
ISSN | 2210-7789 |
IngestDate | Sat Apr 29 05:43:30 EDT 2023 Sat Oct 05 06:22:37 EDT 2024 Thu Sep 26 18:30:12 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | true |
Language | English Norwegian |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c354t-14fcb6b9cc2c9882748147d476b853238e9fb231c884bddef34ef36ad69348133 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | http://hdl.handle.net/10852/98679 |
PQID | 2717696258 |
PQPubID | 23479 |
PageCount | 7 |
ParticipantIDs | cristin_nora_10852_98679 proquest_miscellaneous_2717696258 crossref_primary_10_1016_j_preghy_2022_09_003 |
PublicationCentury | 2000 |
PublicationDate | 2022-12-01 |
PublicationDateYYYYMMDD | 2022-12-01 |
PublicationDate_xml | – month: 12 year: 2022 text: 2022-12-01 day: 01 |
PublicationDecade | 2020 |
PublicationTitle | Pregnancy hypertension |
PublicationYear | 2022 |
References | Wertaschnigg (10.1016/j.preghy.2022.09.003_b0190) 2020; 56 Omland (10.1016/j.preghy.2022.09.003_b0085) 2008; 101 Redman (10.1016/j.preghy.2022.09.003_b0040) 2020 Hill (10.1016/j.preghy.2022.09.003_b0080) 2014; 19 Rafik Hamad (10.1016/j.preghy.2022.09.003_b0165) 2009; 27 Chen (10.1016/j.preghy.2022.09.003_b0180) 2016; 83 Taki (10.1016/j.preghy.2022.09.003_b0095) 2018; 82 Ostermann (10.1016/j.preghy.2022.09.003_b0160) 2017; 47 Roberts (10.1016/j.preghy.2022.09.003_b0140) 2003; 41 Wiklund (10.1016/j.preghy.2022.09.003_b0215) 2010; 9 Brown (10.1016/j.preghy.2022.09.003_b0025) 2018; 137 Lawton (10.1016/j.preghy.2022.09.003_b0100) 1997; 203 Díaz (10.1016/j.preghy.2022.09.003_b0195) 2020; 87 Maniecka-Bryla (10.1016/j.preghy.2022.09.003_b0005) 2013; 71 Lew (10.1016/j.preghy.2022.09.003_b0015) 2017; 135 Jacobsen (10.1016/j.preghy.2022.09.003_b0150) 2021; 143 Staff (10.1016/j.preghy.2022.09.003_b0020) 2016; 67 Frank (10.1016/j.preghy.2022.09.003_b0075) 2008; 51 Dougherty (10.1016/j.preghy.2022.09.003_b0010) 2011; 38 Duley (10.1016/j.preghy.2022.09.003_b0035) 2009; 33 Omland (10.1016/j.preghy.2022.09.003_b0050) 2015; 61 Thygesen (10.1016/j.preghy.2022.09.003_b0045) 2018; 138 von Dadelszen (10.1016/j.preghy.2022.09.003_b0145) 2003; 22 Magga (10.1016/j.preghy.2022.09.003_b0070) 1994; 134 Krieg (10.1016/j.preghy.2022.09.003_b0175) 2010; 30 Ravichandran (10.1016/j.preghy.2022.09.003_b0065) 2019; 132 Cruickshank (10.1016/j.preghy.2022.09.003_b0120) 2021; 10 Johnsen (10.1016/j.preghy.2022.09.003_b0135) 2006; 85 Furuhashi (10.1016/j.preghy.2022.09.003_b0105) 1994; 38 Sato (10.1016/j.preghy.2022.09.003_b0155) 2011; 58 Kim (10.1016/j.preghy.2022.09.003_b0170) 2018; 2018 Sabria (10.1016/j.preghy.2022.09.003_b0125) 2018; 51 Omland (10.1016/j.preghy.2022.09.003_b0055) 2009; 361 Temel Yuksel (10.1016/j.preghy.2022.09.003_b0185) 2018; 37 Tsai (10.1016/j.preghy.2022.09.003_b0200) 2015; 10 Schwartzkopff (10.1016/j.preghy.2022.09.003_b0225) 2000; 36 de Lemos (10.1016/j.preghy.2022.09.003_b0060) 2010; 304 Williams (10.1016/j.preghy.2022.09.003_b0130) 2018; 39 Melchiorre (10.1016/j.preghy.2022.09.003_b0220) 2011; 58 Sadlecki (10.1016/j.preghy.2022.09.003_b0115) 2016; 11 Sugulle (10.1016/j.preghy.2022.09.003_b0210) 2011; 1 Wang (10.1016/j.preghy.2022.09.003_b0090) 2002; 90 Sugulle (10.1016/j.preghy.2022.09.003_b0110) 2009; 54 Moe (10.1016/j.preghy.2022.09.003_b0030) 2020; 27 Muijsers (10.1016/j.preghy.2022.09.003_b0205) 2020; 38 |
References_xml | – volume: 30 start-page: 344 issue: 1 year: 2010 ident: 10.1016/j.preghy.2022.09.003_b0175 article-title: Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00444-09 contributor: fullname: Krieg – volume: 56 start-page: 879 issue: 6 year: 2020 ident: 10.1016/j.preghy.2022.09.003_b0190 article-title: Second- and third-trimester serum levels of growth-differentiation factor-15 in prediction of pre-eclampsia publication-title: Ultrasound Obstet. Gynecol. doi: 10.1002/uog.22070 contributor: fullname: Wertaschnigg – volume: 137 issue: 24 year: 2018 ident: 10.1016/j.preghy.2022.09.003_b0025 publication-title: Circulation doi: 10.1161/CIR.0000000000000582 contributor: fullname: Brown – volume: 38 start-page: 148 issue: 2 year: 2011 ident: 10.1016/j.preghy.2022.09.003_b0010 article-title: Gender balance in cardiovascular research: importance to women's health publication-title: Tex. Heart Inst. J. contributor: fullname: Dougherty – volume: 33 start-page: 130 issue: 3 year: 2009 ident: 10.1016/j.preghy.2022.09.003_b0035 article-title: The global impact of pre-eclampsia and eclampsia publication-title: Semin. Perinatol. doi: 10.1053/j.semperi.2009.02.010 contributor: fullname: Duley – volume: 58 start-page: 226 issue: 3 year: 2011 ident: 10.1016/j.preghy.2022.09.003_b0155 article-title: High-sensitivity cardiac troponin T in essential hypertension publication-title: J. Cardiol. doi: 10.1016/j.jjcc.2011.07.009 contributor: fullname: Sato – volume: 304 start-page: 2503 issue: 22 year: 2010 ident: 10.1016/j.preghy.2022.09.003_b0060 article-title: Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population publication-title: JAMA doi: 10.1001/jama.2010.1768 contributor: fullname: de Lemos – volume: 27 start-page: 1273 issue: 12 year: 2020 ident: 10.1016/j.preghy.2022.09.003_b0030 article-title: Risk prediction of maternal cardiovascular disease one year after hypertensive pregnancy complications or gestational diabetes mellitus publication-title: Eur. J. Prev. Cardiol. doi: 10.1177/2047487319879791 contributor: fullname: Moe – volume: 82 start-page: 2096 issue: 8 year: 2018 ident: 10.1016/j.preghy.2022.09.003_b0095 article-title: Sex differences in the prognostic power of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide for cardiovascular events- the japan morning surge-home blood pressure study publication-title: Circ. J. doi: 10.1253/circj.CJ-18-0375 contributor: fullname: Taki – volume: 54 start-page: 106 issue: 1 year: 2009 ident: 10.1016/j.preghy.2022.09.003_b0110 article-title: Circulating and placental growth-differentiation factor 15 in preeclampsia and in pregnancy complicated by diabetes mellitus publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.109.130583 contributor: fullname: Sugulle – volume: 39 start-page: 3021 issue: 33 year: 2018 ident: 10.1016/j.preghy.2022.09.003_b0130 article-title: 2018 ESC/ESH Guidelines for the management of arterial hypertension publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehy339 contributor: fullname: Williams – volume: 38 start-page: 1948 issue: 10 year: 2020 ident: 10.1016/j.preghy.2022.09.003_b0205 article-title: High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia publication-title: J. Hypertens. doi: 10.1097/HJH.0000000000002497 contributor: fullname: Muijsers – volume: 11 start-page: e0162957 issue: 9 year: 2016 ident: 10.1016/j.preghy.2022.09.003_b0115 article-title: Prenatal clinical assessment of NT-proBNP as a diagnostic tool for preeclampsia, gestational hypertension and gestational diabetes mellitus publication-title: PLoS ONE doi: 10.1371/journal.pone.0162957 contributor: fullname: Sadlecki – volume: 37 start-page: 192 issue: 4 year: 2018 ident: 10.1016/j.preghy.2022.09.003_b0185 article-title: Maternal levels of growth differentiation factor-15 in patients with preeclampsia publication-title: Hypertens. Pregnancy doi: 10.1080/10641955.2018.1524477 contributor: fullname: Temel Yuksel – volume: 138 start-page: e618 issue: 20 year: 2018 ident: 10.1016/j.preghy.2022.09.003_b0045 article-title: Fourth Universal Definition of Myocardial Infarction (2018) publication-title: Circulation doi: 10.1161/CIR.0000000000000617 contributor: fullname: Thygesen – volume: 27 start-page: 2257 issue: 11 year: 2009 ident: 10.1016/j.preghy.2022.09.003_b0165 article-title: Assessment of left ventricular structure and function in preeclampsia by echocardiography and cardiovascular biomarkers publication-title: J. Hypertens. doi: 10.1097/HJH.0b013e3283300541 contributor: fullname: Rafik Hamad – volume: 38 start-page: 73 issue: 2 year: 1994 ident: 10.1016/j.preghy.2022.09.003_b0105 article-title: Brain natriuretic peptide and atrial natriuretic peptide levels in normal pregnancy and preeclampsia publication-title: Gynecol. Obstet. Invest. doi: 10.1159/000292452 contributor: fullname: Furuhashi – volume: 132 start-page: 362 issue: 3 year: 2019 ident: 10.1016/j.preghy.2022.09.003_b0065 article-title: High-sensitivity cardiac troponin I levels in normal and hypertensive pregnancy publication-title: Am. J. Med. doi: 10.1016/j.amjmed.2018.11.017 contributor: fullname: Ravichandran – volume: 85 start-page: 286 issue: 3 year: 2006 ident: 10.1016/j.preghy.2022.09.003_b0135 article-title: Longitudinal reference ranges for estimated fetal weight publication-title: Acta Obstet. Gynecol. Scand. doi: 10.1080/00016340600569133 contributor: fullname: Johnsen – volume: 67 start-page: 251 issue: 2 year: 2016 ident: 10.1016/j.preghy.2022.09.003_b0020 article-title: Pregnancy and long-term maternal cardiovascular health: progress through harmonization of research cohorts and biobanks publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.115.06357 contributor: fullname: Staff – volume: 47 start-page: 702 issue: 6 year: 2017 ident: 10.1016/j.preghy.2022.09.003_b0160 article-title: Cardiac troponin release is associated with biomarkers of inflammation and ventricular dilatation during critical illness publication-title: Shock. doi: 10.1097/SHK.0000000000000811 contributor: fullname: Ostermann – volume: 87 start-page: 897 issue: 5 year: 2020 ident: 10.1016/j.preghy.2022.09.003_b0195 article-title: Circulating growth-and-differentiation factor-15 in early life: relation to prenatal and postnatal growth and adiposity measurements publication-title: Pediatr. Res. doi: 10.1038/s41390-019-0633-z contributor: fullname: Díaz – volume: 41 start-page: 437 issue: 3 year: 2003 ident: 10.1016/j.preghy.2022.09.003_b0140 article-title: Pregnancy NWGoRoHD. Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy publication-title: Hypertension doi: 10.1161/01.HYP.0000054981.03589.E9 contributor: fullname: Roberts – volume: 90 start-page: 254 issue: 3 year: 2002 ident: 10.1016/j.preghy.2022.09.003_b0090 article-title: Impact of age and sex on plasma natriuretic peptide levels in healthy adults publication-title: Am. J. Cardiol. doi: 10.1016/S0002-9149(02)02464-5 contributor: fullname: Wang – volume: 2018 start-page: 1 year: 2018 ident: 10.1016/j.preghy.2022.09.003_b0170 article-title: CRP stimulates GDF15 expression in endothelial cells through p53 publication-title: Mediators Inflamm. contributor: fullname: Kim – volume: 361 start-page: 2538 issue: 26 year: 2009 ident: 10.1016/j.preghy.2022.09.003_b0055 article-title: A sensitive cardiac troponin T assay in stable coronary artery disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0805299 contributor: fullname: Omland – volume: 22 start-page: 143 issue: 2 year: 2003 ident: 10.1016/j.preghy.2022.09.003_b0145 article-title: Subclassification of preeclampsia publication-title: Hypertens Pregnancy. doi: 10.1081/PRG-120021060 contributor: fullname: von Dadelszen – volume: 101 start-page: 61 issue: 3A year: 2008 ident: 10.1016/j.preghy.2022.09.003_b0085 article-title: Amino-terminal pro-B-type natriuretic peptides in stable and unstable ischemic heart disease publication-title: Am. J. Cardiol. doi: 10.1016/j.amjcard.2007.11.025 contributor: fullname: Omland – volume: 10 start-page: e0133362 issue: 7 year: 2015 ident: 10.1016/j.preghy.2022.09.003_b0200 article-title: Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI publication-title: PLoS ONE doi: 10.1371/journal.pone.0133362 contributor: fullname: Tsai – volume: 135 start-page: 544 issue: 6 year: 2017 ident: 10.1016/j.preghy.2022.09.003_b0015 article-title: Sex-based differences in cardiometabolic biomarkers publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.116.023005 contributor: fullname: Lew – volume: 83 start-page: 226 year: 2016 ident: 10.1016/j.preghy.2022.09.003_b0180 article-title: Serum levels of GDF15 are reduced in preeclampsia and the reduction is more profound in late-onset than early-onset cases publication-title: Cytokine doi: 10.1016/j.cyto.2016.05.002 contributor: fullname: Chen – volume: 71 start-page: 1065 issue: 10 year: 2013 ident: 10.1016/j.preghy.2022.09.003_b0005 article-title: Life years lost due to cardiovascular diseases publication-title: Kardiol Pol. doi: 10.5603/KP.2013.0262 contributor: fullname: Maniecka-Bryla – volume: 61 start-page: 646 issue: 4 year: 2015 ident: 10.1016/j.preghy.2022.09.003_b0050 article-title: Impact of sex on the prognostic value of high-sensitivity cardiac troponin I in the general population: the HUNT study publication-title: Clin. Chem. doi: 10.1373/clinchem.2014.234369 contributor: fullname: Omland – volume: 19 start-page: 421 issue: 4 year: 2014 ident: 10.1016/j.preghy.2022.09.003_b0080 article-title: Use of BNP and NT-proBNP for the diagnosis of heart failure in the emergency department: a systematic review of the evidence publication-title: Heart Fail. Rev. doi: 10.1007/s10741-014-9447-6 contributor: fullname: Hill – volume: 10 start-page: e020302 issue: 16 year: 2021 ident: 10.1016/j.preghy.2022.09.003_b0120 article-title: Circulating growth differentiation factor 15 is increased preceding preeclampsia diagnosis: implications as a disease biomarker publication-title: J Am Heart Assoc. doi: 10.1161/JAHA.120.020302 contributor: fullname: Cruickshank – volume: 51 start-page: 309 issue: 2 year: 2008 ident: 10.1016/j.preghy.2022.09.003_b0075 article-title: Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.107.098046 contributor: fullname: Frank – volume: 51 start-page: 758 issue: 6 year: 2018 ident: 10.1016/j.preghy.2022.09.003_b0125 article-title: Addition of N-terminal pro-B natriuretic peptide to soluble fms-like tyrosine kinase-1/placental growth factor ratio > 38 improves prediction of pre-eclampsia requiring delivery within 1 week: a longitudinal cohort study publication-title: Ultrasound Obstet. Gynecol. doi: 10.1002/uog.19040 contributor: fullname: Sabria – volume: 36 start-page: 220 issue: 2 year: 2000 ident: 10.1016/j.preghy.2022.09.003_b0225 article-title: Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease publication-title: Hypertension doi: 10.1161/01.HYP.36.2.220 contributor: fullname: Schwartzkopff – volume: 203 start-page: 17 issue: 1 year: 1997 ident: 10.1016/j.preghy.2022.09.003_b0100 article-title: Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta publication-title: Gene doi: 10.1016/S0378-1119(97)00485-X contributor: fullname: Lawton – volume: 9 start-page: 1057 issue: 6 year: 2010 ident: 10.1016/j.preghy.2022.09.003_b0215 article-title: Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality publication-title: Aging Cell doi: 10.1111/j.1474-9726.2010.00629.x contributor: fullname: Wiklund – volume: 134 start-page: 2505 issue: 6 year: 1994 ident: 10.1016/j.preghy.2022.09.003_b0070 article-title: Brain natriuretic peptide in plasma, atria, and ventricles of vasopressin- and phenylephrine-infused conscious rats publication-title: Endocrinology doi: 10.1210/endo.134.6.8194476 contributor: fullname: Magga – year: 2020 ident: 10.1016/j.preghy.2022.09.003_b0040 article-title: Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways publication-title: Am. J. Obstet. Gynecol. contributor: fullname: Redman – volume: 1 start-page: 294 issue: 3–4 year: 2011 ident: 10.1016/j.preghy.2022.09.003_b0210 article-title: Increased maternal growth-differentiation factor-15 in preeclampsia does not predict endothelial function 5–8 years postpartum publication-title: Pregnancy Hypertens. doi: 10.1016/j.preghy.2011.08.122 contributor: fullname: Sugulle – volume: 58 start-page: 709 issue: 4 year: 2011 ident: 10.1016/j.preghy.2022.09.003_b0220 article-title: Preeclampsia is associated with persistent postpartum cardiovascular impairment publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.111.176537 contributor: fullname: Melchiorre – volume: 143 start-page: 103249 year: 2021 ident: 10.1016/j.preghy.2022.09.003_b0150 article-title: Pregnancy and postpartum levels of circulating maternal sHLA-G in preeclampsia publication-title: J. Reprod. Immunol. doi: 10.1016/j.jri.2020.103249 contributor: fullname: Jacobsen |
SSID | ssj0000450876 |
Score | 2.3164208 |
Snippet | Cardiovascular disease (CVD) is the leading cause of death in women, yet sex-specific risk factors remain understudied. Preeclampsia and other adverse... |
SourceID | cristin proquest crossref |
SourceType | Open Access Repository Aggregation Database |
StartPage | 103 |
Title | Circulating cardiovascular biomarkers during and after preeclampsia: Crosstalk with placental function? |
URI | https://search.proquest.com/docview/2717696258 http://hdl.handle.net/10852/98679 |
Volume | 30 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBahhbGXsSvNbmiwt-IQy7Is7WV0YSNraSmjhb6ZSJHSZOAWx3nI_sP-886RbMdex1j3EBMcIic6H-em75xDyHunrU3ADY1cmjlM3ahIzVMZZUI4J52x8RiLk0_PxPSSH1-lV4PBzw5raVPpkfnxx7qS_5Eq3AO5YpXsPSTbLgo34D3IF64gYbj-k4wny9L48VtYONsnlmJZPTJvynW3EjFMBL8trTWAhNv10k_mmaClBCf8e8jKepqWL5JEoxfIHz3233lpF9inY3t4DVFs6Tnwu9P8Y9Cxus7rhAL2w_NRe66DB_Of5HbdECq_zRYF1pO3mZ6qrD_BDlzLFg-BsXiygl2o8VynKhjr0D68RmMQX4I7H2YGNeq3PpYJ-jMeJx1THPvOCXe1fEg4rMDG2MX1doSP8s1qmy93m2r_ZuxaCmLDblvlYZUcV8nHKve9Y_dZplKI5fePvp5Mz9qkHfi_2MIPBxY2f6Upx_Scwbs_CMIq47V10Xd8-nbfOzMXj8mjOgqhRwFST8jAFk_Jg9OaZ_GMLDrIon1k0R2yaEAWBYFRjyzaRdYH2uKKIq5oiyva4Orjc3L55fPFZBrVIzkik6S8imLujBZaGcOMguAs4zLm2ZxnQoPfB-6fVU5DyGCk5Bosp0s4vMRsLhRWfCfJC7JX3BT2gFAmpE0zBhG1snwutZZOxTydxVxbcHvdkBzUO5cXoA2xk23KcoUNIockarYSpOebsuR_k-eQvGv2OwftiUdis8LebNY5y-JMKMFS-fKea74iD3cQf032qnJj34B_Wum3NWp-AQZDlA0 |
link.rule.ids | 230,315,786,790,891,27957,27958 |
linkProvider | Elsevier |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Circulating+cardiovascular+biomarkers+during+and+after+preeclampsia%3A+Crosstalk+with+placental+function%3F&rft.jtitle=Pregnancy+hypertension&rft.au=Jacobsen%2C+Daniel+P.&rft.au=R%C3%B8ysland%2C+Ragnhild&rft.au=Strand%2C+Heidi&rft.au=Moe%2C+Kjartan&rft.date=2022-12-01&rft.issn=2210-7789&rft.volume=30&rft.spage=103&rft.epage=109&rft_id=info:doi/10.1016%2Fj.preghy.2022.09.003&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_preghy_2022_09_003 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2210-7789&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2210-7789&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2210-7789&client=summon |