Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin‐1c

• Published in: The Journal of pathology Vol. 243; no. 4; pp. 510 - 523
• Main Authors: Liu, Gang, Cooley, Marion A, Nair, Prema M, Donovan, Chantal, Hsu, Alan C, Jarnicki, Andrew G, Haw, Tatt Jhong, Hansbro, Nicole G, Ge, Qi, Brown, Alexandra C, Tay, Hock, Foster, Paul S, Wark, Peter A, Horvat, Jay C, Bourke, Jane E, Grainge, Chris L, Argraves, W Scott, Oliver, Brian G, Knight, Darryl A, Burgess, Janette K, Hansbro, Philip M
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2017; Wiley Subscription Services, Inc
• Subjects: Actin; Actins - metabolism; airway hyperresponsiveness; Airway Remodeling; airway remodelling; allergic airway disease; Animals; Asthma; Asthma - immunology; Asthma - metabolism; Asthma - physiopathology; Asthma - prevention & control; Bronchial Hyperreactivity - immunology; Bronchial Hyperreactivity - metabolism; Bronchial Hyperreactivity - physiopathology; Bronchial Hyperreactivity - prevention & control; Bronchoconstriction; Calcium-Binding Proteins - deficiency; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Cells, Cultured; Clonal deletion; Coculture Techniques; Collagen; Cytokines - genetics; Cytokines - metabolism; Dendritic cells; Disease Models, Animal; Epithelial cells; Extracellular matrix; Extracellular Matrix Proteins - deficiency; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; Fibronectin; fibrosis; fibulin‐1; GATA-3 protein; Genotype; Helper cells; House dust; Humans; inflammation; Inflammation - immunology; Inflammation - metabolism; Inflammation - physiopathology; Inflammation - prevention & control; Inflammation Mediators - metabolism; Interleukin 13; Interleukin 5; Lung - immunology; Lung - metabolism; Lung - physiopathology; lung function; Lungs; Lymph nodes; Lymph Nodes - immunology; Lymph Nodes - metabolism; Lymphatic system; Lymphocytes; Lymphocytes T; Matrix protein; Mice; Mice, Inbred C57BL; Mice, Knockout; mRNA; Mucin; Muscle contraction; Phenotype; Proteins; Respiratory tract diseases; RNA Interference; Rodents; Signal Transduction; Smooth muscle; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Therapeutic targets; Time Factors; Transfection; Tumor necrosis factor; Tumor necrosis factor-TNF; Tumors; United Kingdom > UK; Ireland; allergic airway disease; airway hyperresponsiveness; fibulin-1; lung function; inflammation; airway remodelling; collagen; asthma; fibrosis

Asthma is a chronic inflammatory disease of the airways. It is characterized by allergic airway inflammation, airway remodelling, and airway hyperresponsiveness (AHR). Asthma patients, in particular those with chronic or severe asthma, have airway remodelling that is associated with the accumulation...