Finding the Rhythm of Sudden Cardiac Death: New Opportunities Using Induced Pluripotent Stem Cell–Derived Cardiomyocytes

• Published in: Circulation research Vol. 116; no. 12; pp. 1989 - 2004
• Main Authors: Sallam, Karim, Li, Yingxin, Sager, Philip T., Houser, Steven R., Wu, Joseph C.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 05.06.2015
• Subjects: Animals; Cardiovascular Agents - pharmacology; Cell Differentiation - drug effects; Cells, Cultured; Clinical Trials as Topic - methods; Computer Simulation; Death, Sudden, Cardiac - etiology; Disease Models, Animal; Drug Evaluation, Preclinical - methods; Electrophysiology - methods; Forecasting; Heart Diseases - complications; Heart Diseases - genetics; Heart Diseases - pathology; Humans; Induced Pluripotent Stem Cells - cytology; Ion Channels - physiology; Long QT Syndrome - genetics; Long QT Syndrome - pathology; Long QT Syndrome - physiopathology; Models, Cardiovascular; Myocytes, Cardiac - cytology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - physiology; Organ Culture Techniques; Patch-Clamp Techniques - methods; Tachycardia, Ventricular - genetics; Tachycardia, Ventricular - pathology; Tachycardia, Ventricular - physiopathology; death, sudden, cardiac; induced pluripotent stem cells; cardiovascular diseases; drug discovery

Sudden cardiac death is a common cause of death in patients with structural heart disease, genetic mutations, or acquired disorders affecting cardiac ion channels. A wide range of platforms exist to model and study disorders associated with sudden cardiac death. Human clinical studies are cumbersome...