Enantioselective Construction of Bispirooxindoles via Squaramide‐Catalysed Cascade Michael/Cyclization Reaction

• Published in: Advanced synthesis & catalysis Vol. 361; no. 14; pp. 3387 - 3393
• Main Authors: Zhao, Bo‐Liang, Lin, Ye, Du, Da‐Ming
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 11.07.2019; Wiley Subscription Services, Inc
• Subjects: Bispirooxindoles; Cascade reaction; Catalysis; Chemical synthesis; Chemistry; Chemistry, Applied; Chemistry, Organic; Cyclopentene; Enantiomers; Michael/cyclization; Organocatalysis; Physical Sciences; Science & Technology; Squaramides; Cascade reaction; 3+2 ANNULATION; Bispirooxindoles; ASYMMETRIC-SYNTHESIS; Michael/cyclization; Squaramides; Organocatalysis; CYCLIZATION; SPIROOXINDOLES

A series of readily available 2‐(2‐oxoindolin‐3‐yl)malononitriles bearing multiple active sites were first used in asymmetric catalytic synthesis, which have been successfully applied to develop a bifunctional squaramide‐catalyzed cascade Michael/cyclization reaction strategy. Various cyclopentene‐b...