Metal‐Catalyzed Substrate‐Directed Enantioselective Functionalization of Unactivated Alkenes

• Published in: Chinese journal of chemistry Vol. 37; no. 11; pp. 1174 - 1180
• Main Authors: Wang, Zi‐Xuan, Bai, Xiao‐Yan, Li, Bi‐Jie
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.11.2019; Wiley Subscription Services, Inc
• Subjects: Alkenes; Chemical synthesis; Enantiomers; Functional groups; Organic chemistry; Substrates
• ISSN: 1001-604X; 1614-7065
• DOI: 10.1002/cjoc.201900308

Alkenes are versatile compounds that are available on large scales in industry or through chemical synthesis. Selective functionalization of unactivated alkenes in a chemo‐, regio‐, diastereo‐ and enantioselective fashion is a highly sought‐after goal in organic synthesis. Substrate‐directed enantioselective functionalization of unactivated alkenes provides an important strategy to achieve this goal. Using a functional group on the alkene substrate as a native coordinating group, a two‐point binding mode of the substrate to the metal center enables effective control of regio‐, diastereo‐ and enantioselectivities. Through this strategy, a variety of enantioselective functionalization methods have been developed recently. The recent advances in this area are highlighted here. Recent advances in metal‐catalyzed, substrate‐directed enantioselective functionalization of unactivated alkenes are highlighted.