Model Guided Development of a Simple Catalytic Method for the Synthesis of Unsymmetrical Stilbenes by Sequential Heck Reactions of Aryl Bromides with Ethylene

• Published in: Advanced synthesis & catalysis Vol. 360; no. 14; pp. 2678 - 2690
• Main Authors: Barlow, Helen, Buser, Jonas Y., Glauninger, Hendrik, Luciani, Carla V., Martinelli, Joseph R., Oram, Niall, Thompson‐Van Hook, Nichole, Richardson, Jeffery
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 16.07.2018; Wiley Subscription Services, Inc
• Subjects: Antioxidants; Aromatic compounds; Bromides; Catalysis; Chemical synthesis; Chemistry; Chemistry, Applied; Chemistry, Organic; cross-coupling; Ethylene; ethylene solubility; Heck reaction; Physical Sciences; Pterostilbene; Science & Technology; stilbene; Substrates; unsymmetrical; HALIDES; PALLADIUM; STYRENES; unsymmetrical; STRATEGY; ARYLATION; Heck reaction; ethylene; Pterostilbene; PRESSURE; OLEFINATION; ethylene solubility; cross-coupling; stilbene; CHEMISTRY; EFFICIENT

Stilbenes are important and useful structural moieties, but methods for their preparation typically possess numerous inefficiencies. Presented here is a methodology for the two‐step, one pot preparation of unsymmetrical stilbenes via sequential Heck reactions. The first Heck reaction with ethylene g...