Electrochemical Sulfonylation of Alkynes with Sulfonyl Hydrazides: A Metal‐ and Oxidant‐Free Protocol for the Synthesis of Alkynyl Sulfones

• Published in: Advanced synthesis & catalysis Vol. 362; no. 11; pp. 2160 - 2167
• Main Authors: Mo, Zu‐Yu, Zhang, Yu‐Zhen, Huang, Guo‐Bao, Wang, Xin‐Yu, Pan, Ying‐Ming, Tang, Hai‐Tao
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 26.05.2020; Wiley Subscription Services, Inc
• Subjects: Alkynes; Alkynyl sulfones; Apoptosis; Cell adhesion & migration; Chemistry; Chemistry, Applied; Chemistry, Organic; Cross coupling; Cross-coupling reaction; Electrochemical synthesis; Electrolytic cells; Functional groups; Hydrazides; Oxidizing agents; Physical Sciences; Science & Technology; Sulfones; Sulfonylhydrazine; Terminal alkyne; Transition metals; Terminal alkyne; REAGENTS; STRATEGY; TERMINAL ALKYNES; ACETYLENIC SULFONES; DIARYLSULFONES; Alkynyl sulfones; DIFUNCTIONALIZATION; Sulfonylhydrazine; Cross-coupling reaction; ALKOXYSULFONYLATION; BONDS; INHIBITORS; Electrochemical synthesis

Herein, an electrochemical oxidative cross‐coupling reaction between terminal alkynes and sulfonylhydrazides has been developed. Tetrabutylammonium iodide is used as the electrolyte and redox medium. The significant advantages of this method are high atom efficiency, functional group tolerance, and...