Is HLA Class II Profile Relevant for the Study of Large-Scale Differentially Expressed Genes in Type 1 Diabetes Mellitus Patients?

• Published in: Annals of the New York Academy of Sciences Vol. 1079; no. 1; pp. 305 - 309
• Main Authors: RASSI, DIANE M., JUNTA, CRISTINA M., FACHIN, ANA L., SANDRIN-GARCIA, PAULA, MELLO, STEPHANO S., FERNANDES, ANA P.M., DEGHAIDE, NEIFE N.H.S., FOSS-FREITAS, MARIA C., FOSS, MILTON C., SAKAMOTO-HOJO, ELZA T., PASSOS, GERALDO A.S., DONADI, EDUARDO A.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.10.2006
• Subjects: Algorithms; Alleles; Case-Control Studies; Child; Cluster Analysis; Diabetes Mellitus, Type 1 - diagnosis; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Female; Gene Expression; Histocompatibility Antigens Class II - genetics; HLA-DQ Antigens - genetics; HLA-DR Antigens - genetics; Humans; Male; Metabolism - genetics; metabolism genes; microarrays; Oligonucleotide Array Sequence Analysis; type 1 diabetes mellitus
• ISSN: 0077-8923; 1749-6632; 1930-6547
• DOI: 10.1196/annals.1375.046

:  We have previously identified 30 differentially expressed genes when comparing recently diagnosed type 1 diabetes mellitus (DM‐1) patients and controls paired for sex, age, and ethnic background. In this article we performed the hierarchical clustering of these genes taking into account the human‐leukocyte‐antigen (HLA)‐DRB1/DQB1 profile. The dendrogram obtained using the Cluster program grouped patients and controls into three clusters, one including individuals with no susceptibility alleles, another including individuals with at least three susceptibility alleles, and a third intermingling susceptibility/protective alleles. In addition to other variables, the results of the present article suggest that the major histocompatibility complex (MHC) class II profile may be of relevance for the study of a large‐scale differentially expressed genes.