A Novel Double‐Crosslinking‐Double‐Network Design for Injectable Hydrogels with Enhanced Tissue Adhesion and Antibacterial Capability for Wound Treatment

• Published in: Advanced functional materials Vol. 30; no. 1
• Main Authors: Wang, Lei, Zhang, Xuehui, Yang, Kun, Fu, Yu Vincent, Xu, Tianshun, Li, Shengliang, Zhang, Dawei, Wang, Lu‐Ning, Lee, Chun‐Sing
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.01.2020
• Subjects: Adhesion; antibacterial capability; Biocompatibility; Biodegradability; Carbon; Catechol; Chelation; Chitosan; Crosslinking; Design modifications; double‐crosslinking‐double‐network; Fibrin; Hydrogels; Imidazole; Materials science; Mechanical properties; Modulus of elasticity; Network design; Oxidation; photocrosslinkable and injectable chitosan; Quinones; Shear strength; Skin; tissue adhesion; Tissues; Wound healing

Most photocrosslinkable hydrogels have inadequacy in either mechanical performance or biodegradability. This issue is addressed by adopting a novel hydrogel design by introducing two different chitosan chains (catechol‐modified methacryloyl chitosan, CMC; methacryloyl chitosan, MC) via the simultane...