Preparation of Liquid Crystalline Molecularly Imprinted Polymer Coated Metal Organic Framework for Capecitabine Delivery

• Published in: Particle & particle systems characterization Vol. 36; no. 1
• Main Authors: Zhang, Li‐Ping, Mo, Chun‐E, Huang, Yan‐Ping, Liu, Zhao‐Sheng
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.01.2019
• Subjects: Aqueous solutions; Bioavailability; capecitabine; Controlled release; Crystal structure; Crystallinity; drug delivery; Drug delivery systems; Electron microscopes; Fourier transforms; Gravimetric analysis; HKUST‐1; Image transmission; In vivo methods and tests; Infrared analysis; Infrared imagery; liquid crystal monomer; Liquid crystals; Metal-organic frameworks; molecularly imprinted polymer; Monomers; Pharmacology; Polymer coatings; Polymers; Scanning electron microscopy; Thermal stability; X-ray diffraction
• ISSN: 0934-0866; 1521-4117
• DOI: 10.1002/ppsc.201800355

A novel molecularly imprinted polymer (MIP) coated metal organic framework (MOF) containing a liquid crystalline (LC) monomer is successfully synthesized for use in drug delivery systems. In this study, [Cu3(BTC)2(H2O)3] n (HKUST‐1) is chosen as the MOF support owing to its large pore volume, good diffusion, and thermostability. 4‐Methyl phenyl dicyclohexyl ethylene (MPDE) is used as a LC monomer to increase the solvent‐responsive floating of the composite. The preparation conditions of HKUST‐1@LC‐MIP with capecitabine (CAPE) as a template, including the types of functional monomer, the ratio between template and functional monomer, as well as the content of MPDE, are investigated. Characterizations of the HKUST‐1@LC‐MIP are explored using scanning electron microscopy and transmission electron microscope images, Fourier transform infrared spectroscopy, thermal gravimetric analysis, X‐ray diffraction, and nitrogen adsorption. Compared to the HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro release studies of CAPE of HKUST‐1@LC‐MIP show zero‐order release of profiles at the loaded concentration of 500 µg mL−1. From in vivo pharmacokinetic studies, the HKUST‐1@LC‐MIP displays higher relative bioavailability. It turns out that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration. A novel molecularly imprinted polymer (MIP) coated with metal organic framework containing liquid crystalline (LC) monomer is synthesized for use in drug delivery systems. Compared to HKUST‐1, the HKUST‐1@LC‐MIP shows better stability in aqueous solution. In vitro and in vivo pharmacokinetic studies demonstrate that the HKUST‐1@LC‐MIP possesses the properties of controlled release and has the potentials for oral administration.