Trilobatin Protects Against Aβ25–35-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent Pathway

• Published in: Frontiers in pharmacology Vol. 11; p. 584
• Main Authors: Chen, Nana, Wang, Jiao, He, Yuqi, Xu, Yingshu, Zhang, Yuchuan, Gong, Qihai, Yu, Changyin, Gao, Jianmei
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 19.05.2020
• Subjects: Alzheimer’s disease; Aβ25–35; HT22 cells; p38; Pharmacology; Sirt3; Trilobatin

Emerging evidence reveals that an aberrant accumulation of β-amyloid (Aβ) is the main reason of Alzheimer’s disease (AD) pathogenesis. Thus, inhibition of Aβ-induced neurotoxicity may be promising therapeutic tactics to mitigate AD onset and advance. The development of agent candidates by cultured n...