Microphysiological Systems as Enabling Tools for Modeling Complexity in the Tumor Microenvironment and Accelerating Cancer Drug Development

• Published in: Advanced functional materials Vol. 29; no. 22
• Main Authors: Kim, Hong Nam, Habbit, Nicole L., Su, Chia‐Yi, Choi, Nakwon, Ahn, Eun Hyun, Lipke, Elizabeth A., Kim, Deok‐Ho
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.05.2019
• Subjects: 3D bioprinting; Bioengineering; Biology; Biomimetics; Cancer; Complexity; Hydrogels; In vitro methods and tests; Materials science; Microfluidics; microphysiological systems; paper scaffolds; Platforms; Scaffolds; Spheroids; Three dimensional models; Three dimensional printing; Tissue engineering; topography; tumor microenvironments; Tumors; Two dimensional models

Tumor cell heterogeneity with distinct phenotypes, genotypes, and epigenetic states as well as the complex tumor microenvironment is major challenges for cancer diagnosis and treatment. There have been substantial advances in our knowledge of tumor biology and in the capabilities of available biolog...