Reactive Oxygen Species Inhibit Adhesion of Mesenchymal Stem Cells Implanted into Ischemic Myocardium via Interference of Focal Adhesion Complex

• Published in: Stem cells (Dayton, Ohio) Vol. 28; no. 3; pp. 555 - 563
• Main Authors: Song, Heesang, Cha, Min‐Ji, Song, Byeong‐Wook, Kim, Il‐Kwon, Chang, Woochul, Lim, Soyeon, Choi, Eun Ju, Ham, Onju, Lee, Se‐Yeon, Chung, Namsik, Jang, Yangsoo, Hwang, Ki‐Chul
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 31.03.2010
• Subjects: Acetylcysteine - pharmacology; Adhesion; Animals; Cell Adhesion - drug effects; Cell Adhesion - physiology; Cell Adhesion Molecules - drug effects; Cell Adhesion Molecules - metabolism; Cell Differentiation - physiology; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Focal Adhesion Kinase 1 - drug effects; Focal Adhesion Kinase 1 - metabolism; Focal Adhesions - drug effects; Focal Adhesions - metabolism; Free Radical Scavengers - pharmacology; Gene Knock-In Techniques; Graft Survival - physiology; Hydrogen Peroxide - pharmacology; Integrins - drug effects; Integrins - metabolism; Ischemic heart; Male; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal stem cells; Mesenchymal Stromal Cells - metabolism; Myocardial Ischemia - metabolism; Myocardial Ischemia - physiopathology; Myocardial Ischemia - surgery; Oxidants - pharmacology; Oxidative Stress - drug effects; Oxidative Stress - physiology; Rats; Rats, Sprague-Dawley; Reactive oxygen species; Reactive Oxygen Species - metabolism; Regeneration - physiology; src-Family Kinases - drug effects; src-Family Kinases - metabolism; Transplantation

The integrity of transplanted mesenchymal stem cells (MSCs) for cardiac regeneration is dependent on cell–cell or cell–matrix adhesion, which is inhibited by reactive oxygen species (ROS) generated in ischemic surroundings after myocardial infarction. Intracellular ROS play a key role in the regulat...