A General and Practical Approach for the Synthesis of 1,2,4‐Trioxanes Catalyzed by Silica‐Ferric Chloride

• Published in: Advanced synthesis & catalysis Vol. 359; no. 20; pp. 3618 - 3625
• Main Authors: Zhang, Mo, Han, Yi, Niu, Jia‐Liang, Zhang, Zhan‐Hui
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 25.10.2017; Wiley Subscription Services, Inc
• Subjects: 1,2,4-trioxanes; Alcohols; Carbonyl compounds; Carbonyls; Catalysis; Catalytic activity; Chemical synthesis; Chemistry; Chemistry, Applied; Chemistry, Organic; Ferric chloride; Oxidation; Physical Sciences; Science & Technology; silica-supported iron(III) chloride; Silicon dioxide; β-hydroperoxy alcohols; CONVENIENT SYNTHESIS; 1,2,4-trioxanes; ONE-POT SYNTHESIS; MAGNETICALLY SEPARABLE CATALYST; PROMOTED ONE-POT; carbonyl compounds; beta-hydroperoxy alcohols; silica-supported iron(III) chloride; SUPPORTED MOLYBDENUM; SPIRO 1,2,4-TRIOXANES; DIASTEREOSELECTIVE FORMATION; 4-COMPONENT SYNTHESIS; RECYCLABLE CATALYST; ANTIMALARIAL 1,2,4-TRIOXANES
• ISSN: 1615-4150; 1615-4169
• DOI: 10.1002/adsc.201700671

An efficient and practical method has been developed for the facile synthesis of 1,2,4‐trioxanes by the condensation of β‐hydroperoxy alcohols and carbonyl compounds in the presence of a catalytic amount of silica‐supported ferric chloride (FeCl3/SiO2) at room temperature. The method has the benefits of operational simplicity, high yields and potential large‐scale application. Moreover, the catalyst can be readily recovered by simple filtration and reused up to five times while almost maintaining its catalytic activity.