Melatonin Rescues Renal Mitochondria From Multiple Stressors–Induced Oxidative Stress

• Published in: Basic & clinical pharmacology & toxicology Vol. 136; no. 5; pp. e70031 - n/a
• Main Authors: Alshahrani, Saeed, Sultan, Muhammad H., Rashid, Hina, Alam, Firoz, Khan, Andleeb, Akhter, Mohammad Suhail, Qamri, Derayat, Beigh, Saba, Riyaz, Farhana
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2025
• Subjects: Acetaminophen; Acetaminophen - toxicity; Analgesics; Animals; Antioxidants; Antioxidants - pharmacology; Benzhydryl Compounds - toxicity; Biomarkers - blood; Bisphenol A; Bisphenol A Compounds; Creatinine; Epinephrine; Hydrogen peroxide; Inflammation; Interleukin 6; kidney; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Male; Melatonin; Melatonin - pharmacology; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Phenols - toxicity; Proteins; Rats; Rats, Wistar; Renal function; Superoxide dismutase; Toxins; Tumor necrosis factor-α; Uric acid; Xenobiotics; kidney; acetaminophen; bisphenol A; inflammation; mitochondria; oxidative stress

ABSTRACT The renal system is a significant organ system vulnerable to stress due to its physiological function of toxin elimination. Exposure to a wide array of xenobiotics in humans causes deleterious effects in the kidneys. In the present study, we observed the toxic effect of a coexposure of bisp...