Catalytic Enantioselective Formal Synthesis of MDM2 Antagonist RG7388 and Its Analogues

• Published in: Chinese journal of chemistry Vol. 38; no. 5; pp. 435 - 438
• Main Authors: Zou, Xue‐Jie, Yang, Wu‐Lin, Zhu, Jing‐Yan, Deng, Wei‐Ping
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.05.2020; Wiley; Wiley Subscription Services, Inc
• Subjects: Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Cycloaddition; Enantiomers; MDM2 protein; Physical Sciences; Science & Technology; ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION; PRACTICAL SYNTHESIS; HETEROCYCLES; CONSTRUCTION; AZOMETHINE YLIDES; FRAMEWORK; INHIBITORS

Summary of main observation and conclusion The catalytic asymmetric 1,3‐dipolar [3 + 2] cycloaddition of azomethine ylides with stilbenes has been established, affording structurally diverse pyrrolidines bearing four contiguous stereocenters with stereo‐diversity in generally high yields and good to...