Gut microbiota mitigate the reproductive toxicity of silver nanoparticles through thiamine-derived metabolites

• Published in: Nature communications Vol. 16; no. 1; pp. 7294 - 13
• Main Authors: Gong, Jing-Xi, Wang, Xin-Lei, Lin, Chen-Xin, Li, Xin-Yuan, Wu, Jun, Tan, Qiao-Guo, Yang, Liuyan, Miao, Ai-Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.08.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 14/19; 140/58; 147/143; 38/77; 38/91; 631/326/2565; 631/61/350; 639/925/928/1071; 64/11; 704/172/4081; Animals; Bacteria; Caenorhabditis elegans - drug effects; Caenorhabditis elegans - metabolism; Caenorhabditis elegans - microbiology; Caenorhabditis elegans - physiology; Detoxification; E coli; Exposure; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - physiology; Gene expression; Genetic engineering; Germfree; Gut microbiota; Health risks; Humanities and Social Sciences; Intestinal microflora; Metabolites; Metabolomics; Metal Nanoparticles - chemistry; Metal Nanoparticles - toxicity; Microbiota; Microorganisms; multidisciplinary; Nanoparticles; Nematodes; Reproduction - drug effects; Science; Science (multidisciplinary); Side effects; Silver; Silver - toxicity; Thiamine; Thiamine - metabolism; Toxicity; Toxicity testing; Transmission electron microscopy
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-025-62595-z

The environmental and health risks of silver nanoparticles (AgNPs) have driven the development of numerous engineering strategies to reduce the likelihood of exposure. Nonetheless, AgNP exposure is often inevitable, prompting a search for effective detoxification strategies at the organism level. Gi...