Immunochemical detection of advanced glycosylation end products in vivo
Reducing sugars react with protein amino groups to form a diverse group of protein-bound moieties with fluorescent and cross-linking properties. These compounds, called advanced glycosylation end products (AGEs), have been implicated in the structural and functional alterations of proteins that occu...
Saved in:
Published in | The Journal of biological chemistry Vol. 267; no. 8; pp. 5133 - 5138 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
American Society for Biochemistry and Molecular Biology
15.03.1992
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Reducing sugars react with protein amino groups to form a diverse group of protein-bound moieties with fluorescent and cross-linking
properties. These compounds, called advanced glycosylation end products (AGEs), have been implicated in the structural and
functional alterations of proteins that occur during aging and long-term diabetes. Although several AGEs have been identified
on the basis of de novo synthesis and tissue isolation procedures, the measurement of AGE compounds in vivo has remained difficult.
As an approach to the study of AGE formation in vivo, we prepared polyclonal antiserum to an AGE epitope(s) which forms in
vitro after incubation of glucose with ribonuclease (RNase). This antiserum proved suitable for the detection of AGEs which
form in vivo. Both diabetic tissue and serum known to contain elevated levels of AGEs readily competed for antibody binding.
Cross-reactivity studies revealed the presence of a common AGE epitope(s) which forms after the incubation of diverse proteins
with glucose. Cross-reactive epitopes also formed with glucose 6-phosphate or fructose. These data suggest that tissue AGEs
which form in vivo appear to contain a common immunological epitope which cross-reacts with AGEs prepared in vitro, supporting
the concept that immunologically similar AGE structures form from the incubation of sugars with different proteins (Horiuchi,
S., Araki, N., and Morino, Y. (1991) J. Biol. Chem. 266, 7329-7332). None of the known AGEs, such as 4-furanyl-2-furoyl-1H-imidazole,
1-alkyl-2-formyl-3,4-diglycosylpyrrole, pyrraline, carboxymethyllysine, or pentosidine, were found to compete for binding
to anti-AGE antibody. These data further suggest that the dominant AGE epitope which forms from the reaction of glucose with
proteins under native conditions is immunologically distinct from the structurally defined AGEs described to date. |
---|---|
AbstractList | Reducing sugars react with protein amino groups to form a diverse group of protein-bound moieties with fluorescent and cross-linking
properties. These compounds, called advanced glycosylation end products (AGEs), have been implicated in the structural and
functional alterations of proteins that occur during aging and long-term diabetes. Although several AGEs have been identified
on the basis of de novo synthesis and tissue isolation procedures, the measurement of AGE compounds in vivo has remained difficult.
As an approach to the study of AGE formation in vivo, we prepared polyclonal antiserum to an AGE epitope(s) which forms in
vitro after incubation of glucose with ribonuclease (RNase). This antiserum proved suitable for the detection of AGEs which
form in vivo. Both diabetic tissue and serum known to contain elevated levels of AGEs readily competed for antibody binding.
Cross-reactivity studies revealed the presence of a common AGE epitope(s) which forms after the incubation of diverse proteins
with glucose. Cross-reactive epitopes also formed with glucose 6-phosphate or fructose. These data suggest that tissue AGEs
which form in vivo appear to contain a common immunological epitope which cross-reacts with AGEs prepared in vitro, supporting
the concept that immunologically similar AGE structures form from the incubation of sugars with different proteins (Horiuchi,
S., Araki, N., and Morino, Y. (1991) J. Biol. Chem. 266, 7329-7332). None of the known AGEs, such as 4-furanyl-2-furoyl-1H-imidazole,
1-alkyl-2-formyl-3,4-diglycosylpyrrole, pyrraline, carboxymethyllysine, or pentosidine, were found to compete for binding
to anti-AGE antibody. These data further suggest that the dominant AGE epitope which forms from the reaction of glucose with
proteins under native conditions is immunologically distinct from the structurally defined AGEs described to date. Reducing sugars react with protein amino groups to form a diverse group of protein-bound moieties with fluorescent and cross-linking properties. These compounds, called advanced glycosylation end products (AGEs), have been implicated in the structural and functional alterations of proteins that occur during aging and long-term diabetes. Although several AGEs have been identified on the basis of de novo synthesis and tissue isolation procedures, the measurement of AGE compounds in vivo has remained difficult. As an approach to the study of AGE formation in vivo, we prepared polyclonal antiserum to an AGE epitope(s) which forms in vitro after incubation of glucose with ribonuclease (RNase). This antiserum proved suitable for the detection of AGEs which form in vivo. Both diabetic tissue and serum known to contain elevated levels of AGEs readily competed for antibody binding. Cross-reactivity studies revealed the presence of a common AGE epitope(s) which forms after the incubation of diverse proteins with glucose. Cross-reactive epitopes also formed with glucose 6-phosphate or fructose. These data suggest that tissue AGEs which form in vivo appear to contain a common immunological epitope which cross-reacts with AGEs prepared in vitro, supporting the concept that immunologically similar AGE structures form from the incubation of sugars with different proteins (Horiuchi, S., Araki, N., and Morino, Y. (1991) J. Biol. Chem. 266, 7329-7332). None of the known AGEs, such as 4-furanyl-2-furoyl-1H-imidazole, 1-alkyl-2-formyl-3,4-diglycosylpyrrole, pyrraline, carboxymethyllysine, or pentosidine, were found to compete for binding to anti-AGE antibody. These data further suggest that the dominant AGE epitope which forms from the reaction of glucose with proteins under native conditions is immunologically distinct from the structurally defined AGEs described to date. Advanced glycosylation end products (AGEs) have been implicated in the structural and functional alterations of proteins that occur during aging and long-term diabetes. As an approach to the study of AGE formation in vivo, we prepared polyclonal antiserum to an AGE epitope(s) which forms in vitro after incubation of glucose with ribonuclease (RNase). The data suggest that tissue AGEs which form in vivo appear to contain a common immunological epitope which cross-reacts with AGEs prepared in vitro. |
Author | H Vlassara A Cerami R Bucala Z Makita |
Author_xml | – sequence: 1 givenname: Z surname: MAKITA fullname: MAKITA, Z organization: Rockefeller univ., lab. medical biochemistry, New York NY 10021, United States – sequence: 2 givenname: H surname: VLASSARA fullname: VLASSARA, H organization: Rockefeller univ., lab. medical biochemistry, New York NY 10021, United States – sequence: 3 givenname: A surname: CERAMI fullname: CERAMI, A organization: Rockefeller univ., lab. medical biochemistry, New York NY 10021, United States – sequence: 4 givenname: R surname: BUCALA fullname: BUCALA, R organization: Rockefeller univ., lab. medical biochemistry, New York NY 10021, United States |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5272959$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/1371995$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkctKxDAUhoMoOl4eQSgiootqTtI06VLEGwy4UGF2Ic3FibSNNtPReXszF3RpNln8358cvrOPtrvQWYSOAV8ChvLqGWMCeUWYOAdxURBeQD7ZQiPAguaUwWQbjX6RPbQf4ztOp6hgF-0C5VBVbITuH9t26IKe2tZr1WTGzqye-dBlwWXKzFWnrcnemoUOcdGoVWI7k330wQx6FjPfZXM_D4dox6km2qPNfYBe725fbh7y8dP94831ONeU0e-cFBiMMeCY5SUoo-qioKXjIJxzjNOiMgqIBsKAgqh46VwtsKO1sM5paugBOlu_mwb4HGycydZHbZtGdTYMUXIiCqCE_gtCSSDZYAlka1D3IcbeOvnR-1b1CwlYLk3LlWm51ChByJVpOUm9480HQ91a89daq0356SZXMZl1fVLp4y_GCCcVqxJ2ssam_m365Xsra79ahyQll0ImEZT-AE2uk8g |
CODEN | JBCHA3 |
CitedBy_id | crossref_primary_10_1074_jbc_272_7_4037 crossref_primary_10_1177_002215549704500804 crossref_primary_10_3390_ijms18122557 crossref_primary_10_3390_ijms18122677 crossref_primary_10_1002_rcm_1290080815 crossref_primary_10_1016_j_diabet_2008_05_009 crossref_primary_10_1016_S0272_6386_12_80933_4 crossref_primary_10_1155_2017_9692546 crossref_primary_10_1515_cclm_1996_34_4_355 crossref_primary_10_1021_jf9803132 crossref_primary_10_1016_S0026_0495_00_80029_3 crossref_primary_10_1046_j_1523_1755_1999_00302_x crossref_primary_10_1016_0021_9150_93_90131_D crossref_primary_10_1016_S0891_5849_99_00262_2 crossref_primary_10_1016_S1357_2725_96_00079_9 crossref_primary_10_1097_01_LAB_0000018826_59648_07 crossref_primary_10_1016_S0014_5793_97_00644_3 crossref_primary_10_1016_S0021_9150_97_00221_9 crossref_primary_10_1074_jbc_271_6_2892 crossref_primary_10_1080_10408398_2019_1693958 crossref_primary_10_1007_s00592_018_01278_2 crossref_primary_10_1161_01_ATV_0000131783_74034_97 crossref_primary_10_1002_jms_137 crossref_primary_10_1038_ki_1994_262 crossref_primary_10_2337_db13_1810 crossref_primary_10_1093_jb_mvj092 crossref_primary_10_3892_mmr_2013_1545 crossref_primary_10_1016_S0378_4347_99_00206_6 crossref_primary_10_1016_j_cca_2015_12_004 crossref_primary_10_1017_S0007114508116270 crossref_primary_10_1016_S0009_8981_01_00651_9 crossref_primary_10_1111_j_1471_0528_2012_03463_x crossref_primary_10_1189_jlb_0603265 crossref_primary_10_1007_s00125_003_1056_1 crossref_primary_10_1074_jbc_273_12_6928 crossref_primary_10_1210_endo_142_5_8141 crossref_primary_10_1007_s00394_009_0038_6 crossref_primary_10_1002_1098_2787_2000_19_5_279__AID_MAS3_3_0_CO_2_G crossref_primary_10_1111_j_1463_1326_2006_00595_x crossref_primary_10_1002_mas_21378 crossref_primary_10_1016_S0006_2952_98_00237_8 crossref_primary_10_1016_S0308_8146_00_00238_7 crossref_primary_10_1021_bi9525942 crossref_primary_10_3390_ijms232113036 crossref_primary_10_1007_s11082_015_0129_y crossref_primary_10_1016_j_cbi_2011_01_024 crossref_primary_10_1016_j_cccn_2003_09_007 crossref_primary_10_1016_S1056_8727_00_00079_9 crossref_primary_10_1038_nm1095_1057 crossref_primary_10_1080_10641950802000968 crossref_primary_10_1006_bbrc_1998_9326 crossref_primary_10_1016_S0014_827X_02_01305_8 crossref_primary_10_1016_S0079_6336_99_80006_0 crossref_primary_10_3390_biom9120888 crossref_primary_10_1016_j_mrfmmm_2005_03_024 crossref_primary_10_1016_0272_6386_95_90051_9 crossref_primary_10_1016_j_biochi_2010_12_003 crossref_primary_10_1053_j_jrn_2017_04_003 crossref_primary_10_1016_j_atherosclerosis_2012_10_050 crossref_primary_10_1074_jbc_270_18_10828 crossref_primary_10_1016_S0022_1759_97_00110_5 crossref_primary_10_2337_dc06_1508 crossref_primary_10_1007_BF03346408 crossref_primary_10_1016_j_bcp_2014_09_022 crossref_primary_10_1046_j_1523_1755_1999_t01_1_00298_x crossref_primary_10_1007_BF02815204 crossref_primary_10_1210_endo_138_5_5151 crossref_primary_10_1021_ac503705d crossref_primary_10_1002_dmrr_227 crossref_primary_10_1007_BF03401582 crossref_primary_10_1016_j_ijcard_2016_02_095 crossref_primary_10_1016_0272_6386_95_90107_8 crossref_primary_10_1016_S0140_6736_96_91141_1 crossref_primary_10_1371_journal_pone_0145521 crossref_primary_10_1007_BF00925929 crossref_primary_10_1016_j_mvr_2005_10_001 crossref_primary_10_1002_mas_20187 crossref_primary_10_1046_j_1365_2362_2002_01011_x crossref_primary_10_1016_S0021_9258_17_34043_7 crossref_primary_10_1046_j_1523_1755_1998_00093_x crossref_primary_10_1161_01_RES_0000124920_09738_26 crossref_primary_10_3109_10799899909036650 crossref_primary_10_1538_expanim_49_267 crossref_primary_10_1016_j_yexmp_2016_12_002 crossref_primary_10_1093_ndt_gfg428 crossref_primary_10_1371_journal_pone_0262233 crossref_primary_10_1016_S0168_8278_01_00293_8 crossref_primary_10_1002_jcb_27170 crossref_primary_10_1007_BF00808124 crossref_primary_10_1007_BF03041807 crossref_primary_10_1046_j_1365_2362_2001_00911_x crossref_primary_10_1093_ndt_gfw313 crossref_primary_10_1038_ki_1997_429 crossref_primary_10_1016_S0531_5131_02_00886_5 crossref_primary_10_1073_pnas_94_12_6474 crossref_primary_10_1038_ki_1994_219 crossref_primary_10_1093_glycob_8_2_191 crossref_primary_10_1161_01_ATV_15_5_571 crossref_primary_10_1155_2012_750963 crossref_primary_10_1155_2015_849615 crossref_primary_10_1016_S0891_5849_98_00035_5 crossref_primary_10_1002_jcla_1860070503 crossref_primary_10_1073_pnas_94_25_13915 crossref_primary_10_1016_j_ijbiomac_2017_05_190 crossref_primary_10_1016_S0009_8981_98_00128_4 crossref_primary_10_1194_jlr_M700551_JLR200 crossref_primary_10_1111_1523_1747_ep12292244 crossref_primary_10_1515_CCLM_2003_178 crossref_primary_10_1002_cmdc_201100042 crossref_primary_10_1515_CCLM_2003_179 crossref_primary_10_1016_S0272_6386_03_00747_9 crossref_primary_10_1016_S0021_9258_17_46819_0 crossref_primary_10_1016_S0021_9258_17_36966_1 crossref_primary_10_1021_jf020411u crossref_primary_10_1021_bc990061q crossref_primary_10_1007_s12161_021_01986_6 crossref_primary_10_1111_j_1523_1755_2005_00746_x crossref_primary_10_1152_ajprenal_2001_281_1_F71 crossref_primary_10_1016_0046_8177_95_90063_2 crossref_primary_10_1016_S0022_510X_00_00355_5 crossref_primary_10_1177_089686089501500207 crossref_primary_10_1016_j_neuroscience_2013_10_038 crossref_primary_10_1016_1056_8727_94_00025_J crossref_primary_10_3390_mi12080944 crossref_primary_10_1016_S0022_2275_20_37563_5 crossref_primary_10_1371_journal_pone_0245957 crossref_primary_10_1006_bbrc_2001_4256 crossref_primary_10_1038_ki_1994_62 crossref_primary_10_1161_01_ATV_0000158380_44231_fe crossref_primary_10_1002_sscp_202000077 crossref_primary_10_1097_00004872_200306000_00013 crossref_primary_10_1016_j_vph_2005_03_007 crossref_primary_10_1046_j_1523_1755_2000_00214_x crossref_primary_10_3109_07853899608999102 crossref_primary_10_5551_jat_3624 crossref_primary_10_1016_j_fct_2013_06_052 crossref_primary_10_1016_S0925_4439_00_00071_5 crossref_primary_10_1152_ajpgi_00450_2012 crossref_primary_10_2337_diabetes_52_4_1041 crossref_primary_10_1016_S0022_3476_99_70208_8 crossref_primary_10_1097_00005344_200008000_00017 crossref_primary_10_1111_j_1523_1755_2000_00365_x crossref_primary_10_1006_bioo_1999_1148 crossref_primary_10_1007_BF02869911 crossref_primary_10_1046_j_1365_2133_2001_04275_x crossref_primary_10_1074_jbc_M006545200 crossref_primary_10_1007_s10616_005_1920_6 crossref_primary_10_1016_j_actbio_2006_05_013 crossref_primary_10_3389_fendo_2023_1163554 crossref_primary_10_1007_BF02374476 crossref_primary_10_2337_dc07_0320 crossref_primary_10_1016_S0162_3109_98_00024_1 crossref_primary_10_1002_jcla_20048 crossref_primary_10_1073_pnas_95_4_1758 crossref_primary_10_1016_S0300_9084_97_80029_6 crossref_primary_10_1016_S0002_9440_10_64209_5 crossref_primary_10_1016_S0006_8993_00_03075_4 crossref_primary_10_2119_molmed_2009_00039 crossref_primary_10_1016_j_mehy_2005_11_016 crossref_primary_10_1016_S0021_9258_17_46763_9 crossref_primary_10_1016_S0168_8227_96_01352_6 crossref_primary_10_1038_labinvest_2014_42 crossref_primary_10_1002_jcla_1860070510 crossref_primary_10_1006_abbi_2001_2695 crossref_primary_10_1016_0167_4889_93_90151_E crossref_primary_10_1126_science_1411574 crossref_primary_10_1021_ac3032838 crossref_primary_10_1016_S0047_6374_98_00119_5 crossref_primary_10_1016_0197_4580_96_00116_9 crossref_primary_10_1096_fj_04_2031fje crossref_primary_10_1038_s41598_018_24325_y crossref_primary_10_3233_JAD_190863 crossref_primary_10_1111_j_1460_9568_1998_00287_x crossref_primary_10_1002_mnfr_200500008 crossref_primary_10_1016_S0026_0495_97_90010_X crossref_primary_10_2337_diacare_24_5_891 crossref_primary_10_1016_j_diabet_2012_01_003 crossref_primary_10_1155_2019_4628962 crossref_primary_10_1007_BF03162830 crossref_primary_10_1016_S0925_4439_97_00023_9 crossref_primary_10_1002__SICI_1098_2825_1996_10_1_21__AID_JCLA5_3_0_CO_2_O crossref_primary_10_1016_S0024_3205_98_00374_9 crossref_primary_10_1016_S0026_0495_00_90813_8 crossref_primary_10_3892_mmr_2015_4413 crossref_primary_10_1152_ajprenal_2000_278_4_F676 crossref_primary_10_1016_j_ab_2009_05_019 crossref_primary_10_1006_bbrc_1999_0291 crossref_primary_10_5551_jat_11742 crossref_primary_10_1007_s00125_009_1367_y crossref_primary_10_1007_BF03401604 crossref_primary_10_1038_sj_bjp_0707533 crossref_primary_10_1016_S0304_3940_02_00310_5 crossref_primary_10_1007_BF03401963 crossref_primary_10_1016_j_atherosclerosis_2004_02_012 crossref_primary_10_1038_sj_ki_5002456 crossref_primary_10_1093_ajcn_58_5_779S crossref_primary_10_1016_S0167_4838_98_00255_6 crossref_primary_10_1016_S1262_3636_07_70006_X crossref_primary_10_1016_S0009_9120_02_00302_8 crossref_primary_10_1177_089686080002000413 crossref_primary_10_1111_j_1464_410X_1995_tb07674_x crossref_primary_10_1016_S0002_9440_10_63254_3 crossref_primary_10_2337_diacare_25_6_1055 crossref_primary_10_1177_089686080102100203 crossref_primary_10_1007_BF03345377 crossref_primary_10_1111_j_1432_1033_1997_01000_x crossref_primary_10_1111_j_1749_6632_1998_tb09909_x crossref_primary_10_1016_j_arcmed_2017_07_001 crossref_primary_10_1007_BF03401969 crossref_primary_10_1046_j_1463_1326_2001_00096_x crossref_primary_10_1161_01_CIR_0000074205_17807_D0 crossref_primary_10_1007_BF00926830 crossref_primary_10_1007_BF03343635 crossref_primary_10_1016_S1537_1891_02_00248_3 crossref_primary_10_1007_BF03401759 crossref_primary_10_1021_bi9530550 crossref_primary_10_2337_diabetes_53_7_1813 crossref_primary_10_1111_j_1365_2265_2004_02170_x crossref_primary_10_1517_13543784_10_11_1977 crossref_primary_10_1038_ki_1995_239 crossref_primary_10_1046_j_1523_1755_2003_00752_x crossref_primary_10_1039_c1mb05015j crossref_primary_10_1016_1050_1738_96_00050_3 crossref_primary_10_1016_S0021_9150_97_00192_5 crossref_primary_10_3892_mmr_2017_7837 crossref_primary_10_1016_j_neurobiolaging_2011_12_006 crossref_primary_10_1002_art_21199 crossref_primary_10_1074_jbc_272_28_17473 crossref_primary_10_1007_BF03044692 crossref_primary_10_1016_S0002_9440_10_65659_3 crossref_primary_10_1016_j_bcp_2009_01_010 crossref_primary_10_1515_CCLM_2003_180 crossref_primary_10_1007_BF03401868 crossref_primary_10_1002_dmrr_189 crossref_primary_10_1002_jms_431 crossref_primary_10_1515_CCLM_1999_122 crossref_primary_10_1016_1056_8727_95_80018_A crossref_primary_10_1093_advances_nmaa058 crossref_primary_10_1038_ki_1996_270 crossref_primary_10_1097_MNH_0000000000000062 crossref_primary_10_1111_j_1476_5381_2012_01910_x crossref_primary_10_1053_meta_2003_50035 crossref_primary_10_1007_s00125_007_0687_z crossref_primary_10_1016_j_lfs_2020_117830 crossref_primary_10_1016_S0168_8227_96_01339_3 crossref_primary_10_1046_j_1365_2362_2001_00826_x crossref_primary_10_1016_S0047_6374_01_00400_6 crossref_primary_10_1016_j_jstrokecerebrovasdis_2010_09_002 crossref_primary_10_1016_S0140_6736_94_92935_1 crossref_primary_10_3892_etm_2013_1015 crossref_primary_10_1093_gerona_62_4_427 crossref_primary_10_1186_1472_6882_14_422 crossref_primary_10_2337_diacare_28_3_645 crossref_primary_10_1007_s11239_012_0770_2 crossref_primary_10_1016_j_bbrc_2008_08_008 crossref_primary_10_1016_j_cca_2010_10_018 crossref_primary_10_1002__SICI_1520_7560_200003_04_16_2_74__AID_DMRR80_3_0_CO_2_1 crossref_primary_10_1074_jbc_271_51_32803 crossref_primary_10_1007_BF00403957 crossref_primary_10_1111_prd_12089 crossref_primary_10_1016_S0021_9673_99_00442_2 crossref_primary_10_1038_labinvest_2012_53 crossref_primary_10_1016_0005_2736_94_90230_5 crossref_primary_10_1007_BF03401819 crossref_primary_10_1016_S0272_6386_97_90060_3 crossref_primary_10_3109_08860229909085098 crossref_primary_10_1016_j_lab_2004_04_007 crossref_primary_10_1021_bc5001643 crossref_primary_10_1007_s12010_022_03860_5 crossref_primary_10_1016_j_abb_2012_04_005 crossref_primary_10_1371_journal_pone_0097573 crossref_primary_10_1038_ki_1996_77 crossref_primary_10_1038_ki_1997_497 crossref_primary_10_1038_nrendo_2011_74 crossref_primary_10_1002_ddr_430320204 crossref_primary_10_1002__SICI_1520_7560_200003_04_16_2_106__AID_DMRR88_3_0_CO_2_H crossref_primary_10_1006_bbrc_1998_8945 crossref_primary_10_1007_s10068_019_00704_7 crossref_primary_10_1007_s11064_018_2608_6 crossref_primary_10_1007_s00125_016_4053_x crossref_primary_10_1080_15321810903188136 crossref_primary_10_1515_cclm_1994_32_5_329 crossref_primary_10_1016_S0925_4439_98_00043_X crossref_primary_10_1016_j_ijcard_2004_03_007 crossref_primary_10_1590_2359_3997000000238 crossref_primary_10_1016_j_yexcr_2021_112857 crossref_primary_10_1021_jf960919v crossref_primary_10_1093_glycob_cwn034 crossref_primary_10_1177_089686089701700112 crossref_primary_10_1081_JLC_120005875 crossref_primary_10_1021_acs_jafc_9b04172 crossref_primary_10_2337_diabetes_53_3_743 crossref_primary_10_1074_jbc_M602110200 crossref_primary_10_1016_j_cca_2015_07_029 crossref_primary_10_1073_pnas_95_13_7643 crossref_primary_10_1007_BF03402128 crossref_primary_10_1016_S0022_1759_98_00064_7 crossref_primary_10_1096_fj_02_0490fje crossref_primary_10_1111_j_1432_1033_1995_0408h_x crossref_primary_10_1007_s13197_015_1851_y crossref_primary_10_1093_femspd_ftu004 crossref_primary_10_1038_382275a0 crossref_primary_10_1046_j_1472_8206_2003_00187_x crossref_primary_10_1073_pnas_96_5_2385 crossref_primary_10_1002_mas_20090 crossref_primary_10_1097_00007890_200110270_00006 crossref_primary_10_1161_01_HYP_28_4_583 crossref_primary_10_1371_journal_pone_0118652 crossref_primary_10_1006_mvre_2001_2371 crossref_primary_10_1073_pnas_222561699 crossref_primary_10_1189_jlb_71_3_433 crossref_primary_10_1016_j_ijcard_2011_06_026 crossref_primary_10_1016_j_yexmp_2015_07_009 crossref_primary_10_1111_j_1601_0825_1995_tb00187_x crossref_primary_10_1146_annurev_med_46_1_223 crossref_primary_10_1093_rheumatology_keq380 crossref_primary_10_1007_BF00428771 crossref_primary_10_1093_clinchem_43_9_1563 crossref_primary_10_1096_fj_02_1102fje crossref_primary_10_1016_0197_4580_95_80009_G crossref_primary_10_1016_S0049_3848_97_00028_5 crossref_primary_10_1046_j_1523_1755_1998_00030_x crossref_primary_10_1074_jbc_272_9_5430 crossref_primary_10_3390_nu7064689 crossref_primary_10_1046_j_1365_201x_1999_00623_x crossref_primary_10_1177_1535370213518281 crossref_primary_10_1248_bpb_24_863 crossref_primary_10_1515_JBCPP_2002_13_3_201 crossref_primary_10_5551_jat_3590 crossref_primary_10_1006_mcbr_2000_0243 crossref_primary_10_1111_j_1525_139X_2012_01081_x crossref_primary_10_1074_jbc_272_13_8723 crossref_primary_10_3164_jcbn_2007014 crossref_primary_10_1038_ki_1996_358 crossref_primary_10_1080_00365510510013794 crossref_primary_10_1007_BF03401949 crossref_primary_10_1016_j_bcp_2004_09_006 crossref_primary_10_1016_S0891_5849_02_00904_8 crossref_primary_10_1007_BF01076897 crossref_primary_10_1016_S0026_0495_98_90303_1 crossref_primary_10_1046_j_1523_1755_1998_00091_x |
Cites_doi | 10.1172/JCI114449 10.1056/NEJM199109193251202 10.1016/0006-291X(68)90430-0 10.1016/S0021-9258(20)89449-6 10.1016/S0021-9258(18)89758-7 10.1002/anie.199005653 10.1021/jo00245a039 10.2337/diab.33.1.57 10.1073/pnas.76.1.333 10.1016/0161-5890(83)90159-1 10.1016/0006-291X(80)90852-9 10.1016/S0021-9258(19)84914-1 10.1016/S0021-9258(17)39548-0 10.7326/0003-4819-101-4-527 10.1073/pnas.87.22.9010 10.1056/NEJM198602133140702 10.1126/science.3487117 10.1002/cber.19590921127 10.1016/0008-6215(87)80280-X 10.1016/0006-291X(89)92372-3 10.1073/pnas.81.9.2684 10.1126/science.6779377 10.1016/0076-6879(84)06009-2 10.1016/0003-2697(76)90527-3 10.1016/S0021-9258(17)40461-3 10.1016/S0021-9258(20)88225-8 10.1016/0009-8981(80)90192-8 10.1016/S0021-9258(18)38020-7 10.1016/S0021-9258(19)89188-3 10.1021/bi00450a033 10.1016/0005-2736(89)90293-9 10.1016/S0021-9258(17)44682-5 10.2337/diab.37.7.867 10.1021/ja01115a525 10.1073/pnas.81.2.583 |
ContentType | Journal Article |
Copyright | 1992 INIST-CNRS |
Copyright_xml | – notice: 1992 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QL 8FD C1K FR3 M81 P64 7X8 |
DOI | 10.1016/S0021-9258(18)42741-X |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Bacteriology Abstracts (Microbiology B) Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Biochemistry Abstracts 3 Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Engineering Research Database Technology Research Database Biochemistry Abstracts 3 Bacteriology Abstracts (Microbiology B) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitleList | MEDLINE Engineering Research Database |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Chemistry |
EISSN | 1083-351X |
EndPage | 5138 |
ExternalDocumentID | 10_1016_S0021_9258_18_42741_X 1371995 5272959 267_8_5133 |
Genre | Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S Journal Article |
GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: DK19655 |
GroupedDBID | - 02 08R 186 2WC 3O- 53G 55 5BI 5GY 5RE 5VS 85S AARDX AAWZA AAYJJ ABFLS ABOCM ABPPZ ABPTK ABUFD ABZEH ACNCT ADACO ADBBV ADBIT ADCOW AEILP AENEX AFFNX AFMIJ AIZTS ALMA_UNASSIGNED_HOLDINGS C1A CJ0 CS3 DIK DL DU5 DZ E3Z EBS EJD ET F20 F5P FA8 FRP GJ GX1 H13 HH5 IH2 J5H KM KQ8 L7B LI MVM MYA N9A NHB O0- OHM OHT OK1 P-O P0W P2P R.V RHF RHI RNS RPM SJN TBC TN5 UHB UPT UQL VH1 VQA WH7 WOQ X X7M XFK XHC XJT Y6R YZZ ZA5 ZGI ZY4 --- -DZ -ET -~X .55 .GJ 0SF 18M 29J 34G 39C 4.4 41~ 6TJ 79B AAEDW AAFWJ AAUGY AAXUO AAYOK ABDNZ ABFSI ABRJW ABTAH ACGFO ACSFO ACYGS ADIYS ADNWM AEXQZ AFDAS AFOSN AFPKN AI. AMRAJ AOIJS BAWUL BTFSW E.L FDB GROUPED_DOAJ HYE IQODW QZG ROL TR2 UKR W8F WHG XSW YQT YSK YWH YYP ZE2 ~02 ~KM 0R~ AALRI ADVLN AITUG AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QL 8FD C1K FR3 M81 P64 7X8 |
ID | FETCH-LOGICAL-c353x-2401ddd1f5e761adab4436f718fff57349da12c1251318976ffb80f3b8effc3d3 |
ISSN | 0021-9258 |
IngestDate | Sat Aug 17 03:12:28 EDT 2024 Sat Aug 17 00:17:58 EDT 2024 Fri Aug 23 00:41:04 EDT 2024 Sat Sep 28 08:25:00 EDT 2024 Sun Oct 29 17:10:45 EDT 2023 Tue Jan 05 14:52:11 EST 2021 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 8 |
Keywords | Proteins Vertebrata Mammalia Antigenic determinant Diabetes mellitus Ageing Glycosylation Glucose ELISA assay |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c353x-2401ddd1f5e761adab4436f718fff57349da12c1251318976ffb80f3b8effc3d3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://doi.org/10.1016/s0021-9258(18)42741-x |
PMID | 1371995 |
PQID | 16210045 |
PQPubID | 23462 |
PageCount | 6 |
ParticipantIDs | proquest_miscellaneous_72841323 proquest_miscellaneous_16210045 crossref_primary_10_1016_S0021_9258_18_42741_X pubmed_primary_1371995 pascalfrancis_primary_5272959 highwire_biochem_267_8_5133 |
ProviderPackageCode | RHF RHI |
PublicationCentury | 1900 |
PublicationDate | 1992-03-15 |
PublicationDateYYYYMMDD | 1992-03-15 |
PublicationDate_xml | – month: 03 year: 1992 text: 1992-03-15 day: 15 |
PublicationDecade | 1990 |
PublicationPlace | Bethesda, MD |
PublicationPlace_xml | – name: Bethesda, MD – name: United States |
PublicationTitle | The Journal of biological chemistry |
PublicationTitleAlternate | J Biol Chem |
PublicationYear | 1992 |
Publisher | American Society for Biochemistry and Molecular Biology |
Publisher_xml | – name: American Society for Biochemistry and Molecular Biology |
References | Sell (10.1016/S0021-9258(18)42741-X_bib18) 1990; 85 Bradford (10.1016/S0021-9258(18)42741-X_bib31) 1976; 72 Ahmed (10.1016/S0021-9258(18)42741-X_bib14) 1986; 261 Nakayama (10.1016/S0021-9258(18)42741-X_bib20) 1989; 162 Njoroge (10.1016/S0021-9258(18)42741-X_bib19) 1988; 263 Edward (10.1016/S0021-9258(18)42741-X_bib32) 1980; 104 Monnier (10.1016/S0021-9258(18)42741-X_bib9) 1986; 314 Horiuchi (10.1016/S0021-9258(18)42741-X_bib25) 1985; 260 Nicholls (10.1016/S0021-9258(18)42741-X_bib23) 1989; 60 Monnier (10.1016/S0021-9258(18)42741-X_bib8) 1984; 81 Farmar (10.1016/S0021-9258(18)42741-X_bib13) 1988; 53 Horiuchi (10.1016/S0021-9258(18)42741-X_bib21) 1991; 266 Monnier (10.1016/S0021-9258(18)42741-X_bib1) 1981; 211 Makita (10.1016/S0021-9258(18)42741-X_bib36) 1991; 325 Monnier (10.1016/S0021-9258(18)42741-X_bib35) 1988; 37 Njoroge (10.1016/S0021-9258(18)42741-X_bib10) 1989; 304 Chang (10.1016/S0021-9258(18)42741-X_bib24) 1985; 260 Kohn (10.1016/S0021-9258(18)42741-X_bib7) 1984; 33 Takata (10.1016/S0021-9258(18)42741-X_bib26) 1989; 984 Schwimmer (10.1016/S0021-9258(18)42741-X_bib37) 1953; 75 Koenig (10.1016/S0021-9258(18)42741-X_bib5) 1977; 252 Njoroge (10.1016/S0021-9258(18)42741-X_bib12) 1987; 167 Brownlee (10.1016/S0021-9258(18)42741-X_bib22) 1986; 232 Sell (10.1016/S0021-9258(18)42741-X_bib15) 1989; 264 Fluckiger (10.1016/S0021-9258(18)42741-X_bib29) 1984; 106 Kirstein (10.1016/S0021-9258(18)42741-X_bib28) 1990; 87 Bucala (10.1016/S0021-9258(18)42741-X_bib33) 1983; 20 Dunn (10.1016/S0021-9258(18)42741-X_bib17) 1989; 28 Hayase (10.1016/S0021-9258(18)42741-X_bib16) 1989; 264 Michel (10.1016/S0021-9258(18)42741-X_bib30) 1959; 92 Brownlee (10.1016/S0021-9258(18)42741-X_bib2) 1984; 101 Ledl (10.1016/S0021-9258(18)42741-X_bib3) 1990; 6 Eble (10.1016/S0021-9258(18)42741-X_bib34) 1983; 258 Goldstein (10.1016/S0021-9258(18)42741-X_bib27) 1979; 77 Bookchin (10.1016/S0021-9258(18)42741-X_bib4) 1968; 32 Cohen (10.1016/S0021-9258(18)42741-X_bib6) 1980; 95 Pongor (10.1016/S0021-9258(18)42741-X_bib11) 1984; 81 |
References_xml | – volume: 85 start-page: 380 year: 1990 ident: 10.1016/S0021-9258(18)42741-X_bib18 publication-title: J. Clin. Invest. doi: 10.1172/JCI114449 contributor: fullname: Sell – volume: 325 start-page: 836 year: 1991 ident: 10.1016/S0021-9258(18)42741-X_bib36 publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199109193251202 contributor: fullname: Makita – volume: 32 start-page: 86 year: 1968 ident: 10.1016/S0021-9258(18)42741-X_bib4 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(68)90430-0 contributor: fullname: Bookchin – volume: 266 start-page: 7329 year: 1991 ident: 10.1016/S0021-9258(18)42741-X_bib21 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(20)89449-6 contributor: fullname: Horiuchi – volume: 260 start-page: 482 year: 1985 ident: 10.1016/S0021-9258(18)42741-X_bib25 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)89758-7 contributor: fullname: Horiuchi – volume: 6 start-page: 565 year: 1990 ident: 10.1016/S0021-9258(18)42741-X_bib3 publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.199005653 contributor: fullname: Ledl – volume: 53 start-page: 2346 year: 1988 ident: 10.1016/S0021-9258(18)42741-X_bib13 publication-title: J. Org. Chem. doi: 10.1021/jo00245a039 contributor: fullname: Farmar – volume: 33 start-page: 57 year: 1984 ident: 10.1016/S0021-9258(18)42741-X_bib7 publication-title: Diabetes doi: 10.2337/diab.33.1.57 contributor: fullname: Kohn – volume: 77 start-page: 333 year: 1979 ident: 10.1016/S0021-9258(18)42741-X_bib27 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.76.1.333 contributor: fullname: Goldstein – volume: 20 start-page: 1289 year: 1983 ident: 10.1016/S0021-9258(18)42741-X_bib33 publication-title: Mol. Immunol. doi: 10.1016/0161-5890(83)90159-1 contributor: fullname: Bucala – volume: 95 start-page: 765 year: 1980 ident: 10.1016/S0021-9258(18)42741-X_bib6 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(80)90852-9 contributor: fullname: Cohen – volume: 264 start-page: 3758 year: 1989 ident: 10.1016/S0021-9258(18)42741-X_bib16 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)84914-1 contributor: fullname: Hayase – volume: 260 start-page: 7970 year: 1985 ident: 10.1016/S0021-9258(18)42741-X_bib24 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)39548-0 contributor: fullname: Chang – volume: 101 start-page: 527 year: 1984 ident: 10.1016/S0021-9258(18)42741-X_bib2 publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-101-4-527 contributor: fullname: Brownlee – volume: 87 start-page: 9010 year: 1990 ident: 10.1016/S0021-9258(18)42741-X_bib28 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.87.22.9010 contributor: fullname: Kirstein – volume: 314 start-page: 403 year: 1986 ident: 10.1016/S0021-9258(18)42741-X_bib9 publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198602133140702 contributor: fullname: Monnier – volume: 232 start-page: 1629 year: 1986 ident: 10.1016/S0021-9258(18)42741-X_bib22 publication-title: Science doi: 10.1126/science.3487117 contributor: fullname: Brownlee – volume: 92 start-page: 2836 year: 1959 ident: 10.1016/S0021-9258(18)42741-X_bib30 publication-title: Chem. Ber. doi: 10.1002/cber.19590921127 contributor: fullname: Michel – volume: 167 start-page: 211 year: 1987 ident: 10.1016/S0021-9258(18)42741-X_bib12 publication-title: Carbohydr. Res. doi: 10.1016/0008-6215(87)80280-X contributor: fullname: Njoroge – volume: 162 start-page: 740 year: 1989 ident: 10.1016/S0021-9258(18)42741-X_bib20 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(89)92372-3 contributor: fullname: Nakayama – volume: 81 start-page: 2684 year: 1984 ident: 10.1016/S0021-9258(18)42741-X_bib11 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.81.9.2684 contributor: fullname: Pongor – volume: 211 start-page: 491 year: 1981 ident: 10.1016/S0021-9258(18)42741-X_bib1 publication-title: Science doi: 10.1126/science.6779377 contributor: fullname: Monnier – volume: 106 start-page: 77 year: 1984 ident: 10.1016/S0021-9258(18)42741-X_bib29 publication-title: Methods Enzymol. doi: 10.1016/0076-6879(84)06009-2 contributor: fullname: Fluckiger – volume: 72 start-page: 248 year: 1976 ident: 10.1016/S0021-9258(18)42741-X_bib31 publication-title: Anal. Biochem. doi: 10.1016/0003-2697(76)90527-3 contributor: fullname: Bradford – volume: 252 start-page: 2992 year: 1977 ident: 10.1016/S0021-9258(18)42741-X_bib5 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)40461-3 contributor: fullname: Koenig – volume: 264 start-page: 21597 year: 1989 ident: 10.1016/S0021-9258(18)42741-X_bib15 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(20)88225-8 contributor: fullname: Sell – volume: 104 start-page: 161 year: 1980 ident: 10.1016/S0021-9258(18)42741-X_bib32 publication-title: Clin. Chim. Acta doi: 10.1016/0009-8981(80)90192-8 contributor: fullname: Edward – volume: 263 start-page: 10646 year: 1988 ident: 10.1016/S0021-9258(18)42741-X_bib19 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)38020-7 contributor: fullname: Njoroge – volume: 261 start-page: 4889 year: 1986 ident: 10.1016/S0021-9258(18)42741-X_bib14 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)89188-3 contributor: fullname: Ahmed – volume: 60 start-page: 486 year: 1989 ident: 10.1016/S0021-9258(18)42741-X_bib23 publication-title: Lab. Invest. contributor: fullname: Nicholls – volume: 28 start-page: 9464 year: 1989 ident: 10.1016/S0021-9258(18)42741-X_bib17 publication-title: Biochemistry doi: 10.1021/bi00450a033 contributor: fullname: Dunn – volume: 984 start-page: 273 year: 1989 ident: 10.1016/S0021-9258(18)42741-X_bib26 publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2736(89)90293-9 contributor: fullname: Takata – volume: 304 start-page: 85 year: 1989 ident: 10.1016/S0021-9258(18)42741-X_bib10 publication-title: Prog. Clin. Biol. Res. contributor: fullname: Njoroge – volume: 258 start-page: 9406 year: 1983 ident: 10.1016/S0021-9258(18)42741-X_bib34 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)44682-5 contributor: fullname: Eble – volume: 37 start-page: 867 year: 1988 ident: 10.1016/S0021-9258(18)42741-X_bib35 publication-title: Diabetes doi: 10.2337/diab.37.7.867 contributor: fullname: Monnier – volume: 75 start-page: 4855 year: 1953 ident: 10.1016/S0021-9258(18)42741-X_bib37 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja01115a525 contributor: fullname: Schwimmer – volume: 81 start-page: 583 year: 1984 ident: 10.1016/S0021-9258(18)42741-X_bib8 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.81.2.583 contributor: fullname: Monnier |
SSID | ssj0000491 |
Score | 1.9922781 |
Snippet | Reducing sugars react with protein amino groups to form a diverse group of protein-bound moieties with fluorescent and cross-linking
properties. These... Reducing sugars react with protein amino groups to form a diverse group of protein-bound moieties with fluorescent and cross-linking properties. These... Advanced glycosylation end products (AGEs) have been implicated in the structural and functional alterations of proteins that occur during aging and long-term... |
SourceID | proquest crossref pubmed pascalfrancis highwire |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 5133 |
SubjectTerms | Adolescent advanced glycosylation end products Analytical, structural and metabolic biochemistry Animals Binding, Competitive Biological and medical sciences Collagen - analogs & derivatives Collagen - analysis Cross Reactions detection diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 2 - blood Diabetic Nephropathies - blood Diabetic Nephropathies - therapy Enzyme-Linked Immunosorbent Assay Epitopes - analysis Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Glycated Hemoglobin A - analysis Glycoproteins - analysis Glycoproteins - immunology Glycosylation Humans Immune Sera Kidney Failure, Chronic - blood Kidney Failure, Chronic - therapy Middle Aged Miscellaneous Proteins Rats Rats, Inbred Lew Reference Values Renal Dialysis |
Title | Immunochemical detection of advanced glycosylation end products in vivo |
URI | http://www.jbc.org/content/267/8/5133.abstract https://www.ncbi.nlm.nih.gov/pubmed/1371995 https://search.proquest.com/docview/16210045 https://search.proquest.com/docview/72841323 |
Volume | 267 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELZgPMALgo2JMgZ-AARCGThOGudxqjYGjCFEi_pmxbGNKliC1m6i_PXc2XHcSpv48RKlUWRHd1_tz_bdd4Q8Uay2BqNncPZIsmFaJ6XVKslFDfMZw3vch_xwMjyaZO-m-TTW2HTZJQu1V_-6NK_kf7wKz8CvmCX7D57tG4UHcA_-hSt4GK5_5eO3mNyBJa98zr82C1MHBtgf7n_9vqzb-dLHvL00ThfAqby6SNiL2UW7SlBjqpgjqV6jyauIhNJwcRP728xzz_504wty8cqVLopZDyNzVp3O1vdNUf-2ivGKusvDSzHuyide9mkALClTr7sehtLUl9boMCNWBkYsI7MyycJPcekA7vcSPvetO7Wqp2mZocxOMo2zVjipP_koDyfHx3J8MB1fJzfSoswxsvP9pygaD4sgXzixazMmcr2KHT1n4kXXyTpFCbLRGDVbzcE61lc8uXpJ4qjJ-A653bmL7nuA3CXXTLNJtvabatGeLukz6qJ83fHJJrk5Cm7cIm_W8UN7_NDW0oAfuoYfCvihAT901lDEzz0yOTwYj46SrrBGUvOc_8QTNaa1ZjY3xZBVulJZxocWaIq1Ni94VuqKpTVyXxjygbBaq8Rry5Uw1tZc822y0bSNuU_gy3iplGVKaJGJ0ioDlK-ymjNYJ2dCDchesKX84fVTZAwsBONLNL5kQjrjy-mA7ASLS8A4mkACrKSQCKEB2V1zQt9mnsIqMS8H5HFwigRj4uFX1Zj2fC7ZMEVxxPzqNwpgaoyn0Me292b8YF6gksGDPza-Q27F_8pDsrE4Oze7QFoX6pGD5G_VaJWD |
link.rule.ids | 315,786,790,27955,27956 |
linkProvider | Colorado Alliance of Research Libraries |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immunochemical+detection+of+advanced+glycosylation+end+products+in+vivo&rft.jtitle=The+Journal+of+biological+chemistry&rft.au=Makita%2C+Z&rft.au=Vlassara%2C+H&rft.au=Cerami%2C+A&rft.au=Bucala%2C+R&rft.date=1992-03-15&rft.issn=0021-9258&rft.volume=267&rft.issue=8&rft.spage=5133&rft.epage=5138&rft_id=info:doi/10.1016%2FS0021-9258%2818%2942741-X&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9258&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9258&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9258&client=summon |