Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin αvβ3 for staging liver fibrosis in rat model

• Published in: International journal of nanomedicine Vol. 11; no. default; pp. 1097 - 1108
• Main Authors: Wang, Deng-Bin, Zhang, Caiyuan, Liu, Huanhuan, Cui, Yanfen, Li, Xiaoming, Zhang, Zhongyang, Zhang, Yong
• Format: Journal Article
• Language: English
• Published: New Zealand Taylor & Francis Ltd 2016; Dove Medical Press
• Subjects: Animals; Bile; Carbon Tetrachloride - toxicity; Dextrans - chemistry; Dextrans - metabolism; Disease Models, Animal; Extracellular matrix; Feasibility studies; Gene expression; hepatic stellate cell; Hepatic Stellate Cells - pathology; Hepatic Stellate Cells - physiology; Hepatitis; Hepatology; Hypertension; integrin; Integrin alphaVbeta3 - metabolism; Liver; Liver Cirrhosis - chemically induced; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; liver fibrosis; magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetite Nanoparticles - chemistry; Male; Medical imaging; Nanoparticles; NMR; Nuclear magnetic resonance; Oligopeptides - chemistry; Original Research; Peptides; Rats; ultrasmall superparamagnetic iron oxide; United States > US; China; liver fibrosis; magnetic resonance imaging; ultrasmall superparamagnetic iron oxide; hepatic stellate cell; integrin

To evaluate the expression level of integrin αvβ3 on activated hepatic stellate cells (HSCs) at different stages of liver fibrosis induced by carbon tetrachloride (CCl4) in rat model and the feasibility to stage liver fibrosis by using molecular magnetic resonance imaging (MRI) with arginine-glycine...