Circulating Levels of MicroRNAs in Hypertrophic Cardiomyopathy: The Relationship With Left Ventricular Hypertrophy, Left Atrial Dilatation and Ventricular Depolarisation-Repolarisation Parameters
MicroRNAs are small, endogenous, non-coding RNAs that regulate the expression of many genes. It has recently been shown that circulating microRNAs may be biomarkers of hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy (HCM). To determine whether circulating levels of microRNAs in...
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Published in | Heart, lung & circulation Vol. 31; no. 2; pp. 199 - 206 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.02.2022
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Abstract | MicroRNAs are small, endogenous, non-coding RNAs that regulate the expression of many genes. It has recently been shown that circulating microRNAs may be biomarkers of hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy (HCM).
To determine whether circulating levels of microRNAs involved in HCM are associated with electrocardiographic and echocardiographic parameters.
This study enrolled 20 patients with familial HCM and 20 blood donors. Peripheral serum levels of miR-29a-3p, miR-199a-5p and miR-451a were assessed by quantitative real-time polymerase chain reaction and compared with levels in the control group. Whether circulating levels of miRNAs in HCM patients correlated with electrocardiographic and echocardiographic parameters was also assessed.
Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. Median miR-199a levels did not differ between groups. However, circulating levels of miR-199a negatively correlated with corrected QT duration (Bazett formula). Median miR-29a levels positively correlated with QRS duration. In addition, circulating levels of miR-29a correlated with maximal wall thickness, left ventricular mass index and left atrial volume index.
The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients. As the circulating level of miR-29a correlated with QRS duration, left ventricular hypertrophy and left atrial dilatation, the serum miR-199a level negatively correlated with corrected QT duration. These miRNAs may be seen as potential biomarkers for further research in HCM pathophysiology. |
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AbstractList | BACKGROUNDMicroRNAs are small, endogenous, non-coding RNAs that regulate the expression of many genes. It has recently been shown that circulating microRNAs may be biomarkers of hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy (HCM). OBJECTIVETo determine whether circulating levels of microRNAs involved in HCM are associated with electrocardiographic and echocardiographic parameters. METHODSThis study enrolled 20 patients with familial HCM and 20 blood donors. Peripheral serum levels of miR-29a-3p, miR-199a-5p and miR-451a were assessed by quantitative real-time polymerase chain reaction and compared with levels in the control group. Whether circulating levels of miRNAs in HCM patients correlated with electrocardiographic and echocardiographic parameters was also assessed. RESULTSMedian circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. Median miR-199a levels did not differ between groups. However, circulating levels of miR-199a negatively correlated with corrected QT duration (Bazett formula). Median miR-29a levels positively correlated with QRS duration. In addition, circulating levels of miR-29a correlated with maximal wall thickness, left ventricular mass index and left atrial volume index. CONCLUSIONSThe data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients. As the circulating level of miR-29a correlated with QRS duration, left ventricular hypertrophy and left atrial dilatation, the serum miR-199a level negatively correlated with corrected QT duration. These miRNAs may be seen as potential biomarkers for further research in HCM pathophysiology. MicroRNAs are small, endogenous, non-coding RNAs that regulate the expression of many genes. It has recently been shown that circulating microRNAs may be biomarkers of hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy (HCM). To determine whether circulating levels of microRNAs involved in HCM are associated with electrocardiographic and echocardiographic parameters. This study enrolled 20 patients with familial HCM and 20 blood donors. Peripheral serum levels of miR-29a-3p, miR-199a-5p and miR-451a were assessed by quantitative real-time polymerase chain reaction and compared with levels in the control group. Whether circulating levels of miRNAs in HCM patients correlated with electrocardiographic and echocardiographic parameters was also assessed. Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. Median miR-199a levels did not differ between groups. However, circulating levels of miR-199a negatively correlated with corrected QT duration (Bazett formula). Median miR-29a levels positively correlated with QRS duration. In addition, circulating levels of miR-29a correlated with maximal wall thickness, left ventricular mass index and left atrial volume index. The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients. As the circulating level of miR-29a correlated with QRS duration, left ventricular hypertrophy and left atrial dilatation, the serum miR-199a level negatively correlated with corrected QT duration. These miRNAs may be seen as potential biomarkers for further research in HCM pathophysiology. |
Author | Sonsöz, Mehmet Rasih Elitok, Ali Cevik, Erdem Onur, Imran Komurcu-Bayrak, Evrim Bilge, Ahmet Kaya Yilmaz, Mustafa Orta, Huseyin |
Author_xml | – sequence: 1 givenname: Mehmet Rasih surname: Sonsöz fullname: Sonsöz, Mehmet Rasih email: mrsonsoz@gmail.com organization: Department of Cardiology, Basaksehir Pine and Sakura City Hospital, Istanbul, Turkey – sequence: 2 givenname: Mustafa surname: Yilmaz fullname: Yilmaz, Mustafa organization: Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey – sequence: 3 givenname: Erdem surname: Cevik fullname: Cevik, Erdem organization: Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey – sequence: 4 givenname: Huseyin surname: Orta fullname: Orta, Huseyin organization: Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey – sequence: 5 givenname: Ahmet Kaya surname: Bilge fullname: Bilge, Ahmet Kaya organization: Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey – sequence: 6 givenname: Ali surname: Elitok fullname: Elitok, Ali organization: Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey – sequence: 7 givenname: Imran surname: Onur fullname: Onur, Imran organization: Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey – sequence: 8 givenname: Evrim surname: Komurcu-Bayrak fullname: Komurcu-Bayrak, Evrim organization: Department of Genetics, Aziz Sancar Institute of Experimental Medicine and Department of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34088630$$D View this record in MEDLINE/PubMed |
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Keywords | Electrocardiography Hypertrophic cardiomyopathy Echocardiography MicroRNA |
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Snippet | MicroRNAs are small, endogenous, non-coding RNAs that regulate the expression of many genes. It has recently been shown that circulating microRNAs may be... BACKGROUNDMicroRNAs are small, endogenous, non-coding RNAs that regulate the expression of many genes. It has recently been shown that circulating microRNAs... |
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SubjectTerms | Cardiomyopathy, Hypertrophic - diagnosis Cardiomyopathy, Hypertrophic - genetics Circulating MicroRNA - genetics Dilatation Echocardiography Electrocardiography Fibrosis Humans Hypertrophic cardiomyopathy Hypertrophy, Left Ventricular - diagnosis Hypertrophy, Left Ventricular - genetics MicroRNA MicroRNAs |
Title | Circulating Levels of MicroRNAs in Hypertrophic Cardiomyopathy: The Relationship With Left Ventricular Hypertrophy, Left Atrial Dilatation and Ventricular Depolarisation-Repolarisation Parameters |
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