Using Objective Vision Measures to Explore the Association of Vision Impairment With Cognition Among Older Adults in the United States

• Published in: American journal of ophthalmology Vol. 255; pp. 18 - 29
• Main Authors: Almidani, Louay, Varadaraj, Varshini, Mihailovic, Aleksandra, Ramulu, Pradeep Y.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2023
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/j.ajo.2023.05.020

To evaluate the association between vision impairment (VI) and cognitive function using objective measures. Cross-sectional analysis with a nationally representative sample. The association between VI and dementia was investigated in a US population-based, nationally representative sample of Medicare beneficiaries, the National Health and Aging Trends Study (NHATS), a nationally representative sample of Medicare beneficiaries aged ≥65 years, using objective vision measures. Exposures included distance VI (>20/40), near VI (>20/40), contrast sensitivity impairment (CSI) (<1.55), any objective VI (distance and near visual acuity, or contrast), and self-reported VI. The main outcome measure was dementia status defined based on survey reports, interviews, and cognitive tests. A total of 3026 adults were included in this study; the majority were female (55%) and White (82%). The weighted prevalence rates were 10% for distance VI, 22% for near VI, 22% for CSI, 34% for any objective VI, and 7% for self-reported VI. Across all measures of VI, dementia was more than twice as prevalent in adults with VI compared to their peers without (P < .001 for all). In adjusted models, all measures of VI were associated with higher odds of dementia (distance VI: OR 1.74, 95% CI 1.24-2.44; near VI: OR 1.68, 95% CI 1.29-2.18; CSI: OR 1.95, 95% CI 1.45-2.62; any objective VI: OR 1.83, 95% CI 1.43-2.35; self-reported VI: OR 1.86, 95% CI 1.20-2.89). In a nationally representative sample of older US adults, VI was associated with increased odds of dementia. These results suggest that maintaining good vision and eye health may help preserve cognitive function in older age, although more research is needed to investigate the potential benefits of interventions that focus on vision and eye health on cognitive outcomes.