tRNA-derived fragments: Key determinants of cancer metastasis with emerging therapeutic and diagnostic potentials
Metastasis is a significant clinical challenge responsible for cancer mortality and non-response to treatment. However, the molecular mechanisms driving metastasis remain unclear, limiting the development of efficient diagnostic and therapeutic approaches. Recent breakthroughs in cancer biology have...
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| Published in | Archives of biochemistry and biophysics Vol. 753; p. 109930 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.03.2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0003-9861 1096-0384 1096-0384 |
| DOI | 10.1016/j.abb.2024.109930 |
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| Abstract | Metastasis is a significant clinical challenge responsible for cancer mortality and non-response to treatment. However, the molecular mechanisms driving metastasis remain unclear, limiting the development of efficient diagnostic and therapeutic approaches. Recent breakthroughs in cancer biology have discovered a group of small non-coding RNAs called tRNA-derived fragments (tRFs), which play a critical role in the metastatic behavior of various tumors. tRFs are produced from cleavage modifications of tRNAs and have different functional classes based on the pattern of these modifications. They perform post-transcriptional regulation through microRNA-like functions, displacing RNA-binding proteins, and play a role in translational regulation by inducing ribosome synthesis, translation initiation, and epigenetic regulation. Tumor cells manipulate tRFs to develop and survive the tumor mass, primarily by inducing metastasis. Multiple studies have demonstrated the potential of tRFs as therapeutic, diagnostic, and prognostic targets for tumor metastasis. This review discusses the production and function of tRFs in cells, their aberrant molecular contributions to the metastatic environment, and their potential as promising targets for anti-metastasis treatment strategies.
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•tRNA-derived fragments (tRFs) participate in the regulation of mRNA stability, epigenetic processes, and translation.•Tumor cells manipulate the expression pattern of specific tRFs to induce metastatic phenotype.•tRFs hold promise as potential diagnostic biomarkers and therapeutic targets in the management of metastasis. |
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| AbstractList | Metastasis is a significant clinical challenge responsible for cancer mortality and non-response to treatment. However, the molecular mechanisms driving metastasis remain unclear, limiting the development of efficient diagnostic and therapeutic approaches. Recent breakthroughs in cancer biology have discovered a group of small non-coding RNAs called tRNA-derived fragments (tRFs), which play a critical role in the metastatic behavior of various tumors. tRFs are produced from cleavage modifications of tRNAs and have different functional classes based on the pattern of these modifications. They perform post-transcriptional regulation through microRNA-like functions, displacing RNA-binding proteins, and play a role in translational regulation by inducing ribosome synthesis, translation initiation, and epigenetic regulation. Tumor cells manipulate tRFs to develop and survive the tumor mass, primarily by inducing metastasis. Multiple studies have demonstrated the potential of tRFs as therapeutic, diagnostic, and prognostic targets for tumor metastasis. This review discusses the production and function of tRFs in cells, their aberrant molecular contributions to the metastatic environment, and their potential as promising targets for anti-metastasis treatment strategies. Metastasis is a significant clinical challenge responsible for cancer mortality and non-response to treatment. However, the molecular mechanisms driving metastasis remain unclear, limiting the development of efficient diagnostic and therapeutic approaches. Recent breakthroughs in cancer biology have discovered a group of small non-coding RNAs called tRNA-derived fragments (tRFs), which play a critical role in the metastatic behavior of various tumors. tRFs are produced from cleavage modifications of tRNAs and have different functional classes based on the pattern of these modifications. They perform post-transcriptional regulation through microRNA-like functions, displacing RNA-binding proteins, and play a role in translational regulation by inducing ribosome synthesis, translation initiation, and epigenetic regulation. Tumor cells manipulate tRFs to develop and survive the tumor mass, primarily by inducing metastasis. Multiple studies have demonstrated the potential of tRFs as therapeutic, diagnostic, and prognostic targets for tumor metastasis. This review discusses the production and function of tRFs in cells, their aberrant molecular contributions to the metastatic environment, and their potential as promising targets for anti-metastasis treatment strategies.Metastasis is a significant clinical challenge responsible for cancer mortality and non-response to treatment. However, the molecular mechanisms driving metastasis remain unclear, limiting the development of efficient diagnostic and therapeutic approaches. Recent breakthroughs in cancer biology have discovered a group of small non-coding RNAs called tRNA-derived fragments (tRFs), which play a critical role in the metastatic behavior of various tumors. tRFs are produced from cleavage modifications of tRNAs and have different functional classes based on the pattern of these modifications. They perform post-transcriptional regulation through microRNA-like functions, displacing RNA-binding proteins, and play a role in translational regulation by inducing ribosome synthesis, translation initiation, and epigenetic regulation. Tumor cells manipulate tRFs to develop and survive the tumor mass, primarily by inducing metastasis. Multiple studies have demonstrated the potential of tRFs as therapeutic, diagnostic, and prognostic targets for tumor metastasis. This review discusses the production and function of tRFs in cells, their aberrant molecular contributions to the metastatic environment, and their potential as promising targets for anti-metastasis treatment strategies. Metastasis is a significant clinical challenge responsible for cancer mortality and non-response to treatment. However, the molecular mechanisms driving metastasis remain unclear, limiting the development of efficient diagnostic and therapeutic approaches. Recent breakthroughs in cancer biology have discovered a group of small non-coding RNAs called tRNA-derived fragments (tRFs), which play a critical role in the metastatic behavior of various tumors. tRFs are produced from cleavage modifications of tRNAs and have different functional classes based on the pattern of these modifications. They perform post-transcriptional regulation through microRNA-like functions, displacing RNA-binding proteins, and play a role in translational regulation by inducing ribosome synthesis, translation initiation, and epigenetic regulation. Tumor cells manipulate tRFs to develop and survive the tumor mass, primarily by inducing metastasis. Multiple studies have demonstrated the potential of tRFs as therapeutic, diagnostic, and prognostic targets for tumor metastasis. This review discusses the production and function of tRFs in cells, their aberrant molecular contributions to the metastatic environment, and their potential as promising targets for anti-metastasis treatment strategies. [Display omitted] •tRNA-derived fragments (tRFs) participate in the regulation of mRNA stability, epigenetic processes, and translation.•Tumor cells manipulate the expression pattern of specific tRFs to induce metastatic phenotype.•tRFs hold promise as potential diagnostic biomarkers and therapeutic targets in the management of metastasis. |
| ArticleNumber | 109930 |
| Author | Saeedi, Fatemeh Kamali, Mohammad Javad Daraei, Abdolreza Rajabzadeh, Aliakbar Minoo, Shima Salehi, Mohammad Mosharafi, Hamidreza |
| Author_xml | – sequence: 1 givenname: Mohammad surname: Salehi fullname: Salehi, Mohammad organization: Department of Medical Genetics, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran – sequence: 2 givenname: Mohammad Javad surname: Kamali fullname: Kamali, Mohammad Javad organization: Department of Medical Genetics, School of Medicine, Babol University of Medical Sciences, Babol, Iran – sequence: 3 givenname: Aliakbar surname: Rajabzadeh fullname: Rajabzadeh, Aliakbar organization: Department of Anatomical Sciences, School of Medicine, Babol University of Medical Sciences, Babol, Iran – sequence: 4 givenname: Shima surname: Minoo fullname: Minoo, Shima organization: Department of Dentistry, Khorasgan Branch, Islamic Azad University, Isfahan, Iran – sequence: 5 givenname: Hamidreza surname: Mosharafi fullname: Mosharafi, Hamidreza organization: School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran – sequence: 6 givenname: Fatemeh surname: Saeedi fullname: Saeedi, Fatemeh organization: Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran – sequence: 7 givenname: Abdolreza surname: Daraei fullname: Daraei, Abdolreza email: a.daraei@mubabol.ac.ir organization: Department of Medical Genetics, School of Medicine, Babol University of Medical Sciences, Babol, Iran |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38369227$$D View this record in MEDLINE/PubMed |
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| Keywords | microRNA Biomarker Metastasis Diagnosis tRNA-derived fragment Cancer |
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