The rostromedial tegmental nucleus modulates the development of stress-induced helpless behavior

• Published in: Behavioural brain research Vol. 359; pp. 950 - 957
• Main Authors: Elmer, G.I., Palacorolla, H., Mayo, C.L., Brown, P.L., Jhou, T.C., Brady, D., Shepard, P.D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2019
• Subjects: Animals; Depression; Depression - etiology; Depression - pathology; Despair; Disease Models, Animal; Electric Stimulation - adverse effects; Electroshock - adverse effects; Habenula; Habenula - physiology; Helplessness, Learned; Learned helplessness; Male; Phosphopyruvate Hydratase - metabolism; Quinolinic Acid - toxicity; Rats; Rats, Sprague-Dawley; RMTg; Stress, Psychological - etiology; Tegmentum Mesencephali - injuries; Tegmentum Mesencephali - physiology; Time Factors; tVTA; RMTg; Depression; tVTA; Learned helplessness; Despair; Habenula

•Functional changes in the habenula (Hb) are associated with depression.•A major projection from the Hb targets the rostromedial tegmentum (RMTg).•RMTg lesions significantly diminished the expression of stress-induced helpless behavior.•Conversely, increased RMTg activity via Hb stimulation increase...