The allosteric dopamine D1 receptor potentiator, DETQ, ameliorates subchronic phencyclidine-induced object recognition memory deficits and enhances cortical acetylcholine efflux in male humanized D1 receptor knock-in mice

• Published in: Behavioural brain research Vol. 361; pp. 139 - 150
• Main Authors: Meltzer, Herbert Y., Rajagopal, Lakshmi, Matrisciano, Francesco, Hao, Junliang, Svensson, Kjell A., Huang, Mei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2019
• Subjects: Acetylcholine; Alzheimer’s and Parkinson’s; DETQ; Dopamine D1 receptor; Rivastigmine; Schizophrenia; RT; TET; DI; ACh; NT; Alzheimer’s and Parkinson’s; Schizophrenia; SCZ; PFC; AUC; Glu; hD1; Rivastigmine; Dopamine D1 receptor; WT; LMA; DETQ; AD; CI; AAPDs; HIP; NOR; Sc; AT; SED; PD; NE; NMDAR; Acetylcholine; PCP; DA; PAM; E/I

•The D1 receptor PAM DETQ restored NOR in scPCP-treated hD1 knock-in mice.•The efficacy of DETQ on NOR was blocked by the D1R antagonist, SCH391660.•There was no inverted U-shaped dose response curve or tolerance in the NOR test.•Rivastigmine, with or without DETQ, reversed the deficit in NOR.•DETQ...