Chemical synthesis of febrifugine and analogues - Smullen, Shaun; McLaughlin, Noel P.; Evans, Paul (Bioorganic & medicinal chemistry, 2018)
Keywords: 3-hydroxypiperidine; Animals; Anti-angiogenic; Anti-fibrotic; Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-protozoal; Antimalarials - chemical synthesis; Antimalarials - chemistry; Antimalarials - pharmacology; Cyclization; Cycloaddition Reaction; Dichroine A and B; Febrifugine; Halofuginone; Humans; Isofebrifugine; Isomerization; Piperidines - chemical synthesis; Piperidines - chemistry; Piperidines - pharmacology; Plasmodium falciparum - drug effects; Quinazolines - chemical synthesis; Quinazolines - chemistry; Quinazolines - pharmacology; Quinazolinone; Quinazolinones - chemical synthesis; Quinazolinones - chemistry; Quinazolinones - pharmacology; Stereoisomerism; de; RNA; DMSO; AD-mix; Red-Al; Isofebrifugine; TFA; Dichroine A and B; Tf; sec-Bu; DBU; Boc; Ph; Quinazolinone; Tp; NBS; TIPS; Ts; ee; IL; TBS; DIPEA; HMBC; TBDPS; DIBAL; CAL-B; CAN; TGF; TBAF; Cat; Grubbs catalyst 1st gen; Me; Ig; Anti-fibrotic; Ac; 3-hydroxypiperidine; Ms; I; Et; Grubbs catalyst 2nd gen; IFN; DMAP; t-Bu; Cbz; PPTS; Febrifugine; DPPA; Anti-protozoal; PMB; MCPBA; DMP; Isomerization; h; LiHMDS; MOM; Bn; Anti-angiogenic; NMM; Halofuginone; NMO; Bu; TH; Bz; NOESY; DEAD; TMS; ATP