Protein kinase inhibitor peptide (PKI): A family of endogenous neuropeptides that modulate neuronal cAMP-dependent protein kinase function

• Published in: Neuropeptides (Edinburgh) Vol. 40; no. 1; pp. 23 - 34
• Main Authors: Dalton, George D., Dewey, William L.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.02.2006; Elsevier
• Subjects: Animals; Biological and medical sciences; Brain; cAMP-dependent protein kinase; Cyclic AMP-Dependent Protein Kinases - metabolism; Fundamental and applied biological sciences. Psychology; Humans; Neurons - enzymology; Neuropeptides - physiology; Nuclear export signal; Peptide Fragments - pharmacology; Peptides - pharmacology; Peptides - physiology; PKA; PKI; Protein kinase A; Protein kinase inhibitor peptide; Signal Transduction; Vertebrates: endocrinology; Protein kinase A; Brain; Protein kinase inhibitor peptide; PKA; cAMP-dependent protein kinase; PKI; Nuclear export signal; Peptides; Enzyme; Transferases; Neuropeptide; Endogenous; Protein kinase

Signal transduction cascades involving cAMP-dependent protein kinase are highly conserved among a wide variety of organisms. Given the universal nature of this enzyme it is not surprising that cAMP-dependent protein kinase plays a critical role in numerous cellular processes. This is particularly ev...