Diabetes alters inflammation, angiogenesis, and fibrogenesis in intraperitoneal implants in rats

• Published in: Microvascular research Vol. 93; pp. 23 - 29
• Main Authors: Oviedo-Socarrás, Teresa, Vasconcelos, Anilton C., Barbosa, Irma X., Pereira, Nubia B., Campos, Paula P., Andrade, Silvia P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2014
• Subjects: Animals; Chemokine CCL2 - metabolism; Collagen - metabolism; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Ethers - adverse effects; Fibrosis; Foreign-Body Reaction - etiology; Foreign-Body Reaction - metabolism; Foreign-Body Reaction - pathology; Hemoglobins - metabolism; Inflammation - etiology; Inflammation - metabolism; Inflammation - pathology; Inflammation Mediators - metabolism; Male; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism; Polyurethanes - adverse effects; Rats, Wistar; Surgical Sponges - adverse effects; Time Factors; Transforming Growth Factor beta1 - metabolism; Tumor Necrosis Factor-alpha - metabolism; Vascular Endothelial Growth Factor A - metabolism; Wound Healing

The increased prevalence of diabetes worldwide is associated with increasing numbers of diabetic individuals receiving synthetic matrices and biomedical implants to repair and/or replace biological tissues. This therapeutic procedure invariably leads to adverse tissue healing (foreign body reaction)...